Table 4 Medication pathway of antidepressants for the MDS group in each regimen
Switch | Top5 | 1st regimen | Â | ||||
Medication | n(%) | Â | |||||
0 time (n = 2661) | 1 | SSRI + AP | 730 (27.43) |  | |||
2 | SSRI | 643 (24.16) | Â | ||||
3 | SNRI + AP | 273 (10.26) |  | ||||
4 | SNRI | 178 (6.69) | 2nd regimen | Â | |||
5 | SSRI + AP + MS | 106 (3.98) | Medication | n(%) |  | ||
1 time (n = 850) | 1 | SSRI | 177 (20.82) | SSRI + AP | 111 (62.71) |  | |
|  |  |  | SSRI + MS | 23 (12.99) |  | ||
|  |  |  | SSRI + NaSSA | 19 (10.73) |  | ||
2 | SSRI + AP | 128 (15.06) | SSRI + AP + MS | 44 (34.38) |  | ||
| Â | Â | Â | SSRI | 22 (17.19) | Â | ||
| Â | Â | Â | AP | 15 (11.72) | Â | ||
3 | AP | 66 (7.76) | SSRI + AP | 27 (40.91) |  | ||
|  |  |  | AP + MS | 24 (36.36) |  | ||
|  |  |  | SNRI + AP | 9 (13.64) |  | ||
4 | SNRI | 58 (6.82) | SNRI + AP | 37 (63.79) |  | ||
|  |  |  | NaSSA + SNRI | 8 (13.79) |  | ||
|  |  |  | SNRI + MS | 3 (5.17) |  | ||
5 | SNRI + AP | 45 (5.29) | SNRI | 10 (22.22) |  | ||
|  |  |  | NaSSA + SNRI + AP | 9 (20.00) | 3rd regimen | ||
|  |  |  | SNRI + other + AP | 7 (15.56) | Medication | n(%) | |
2 times (n = 405) | 1 | SSRI + AP | 86 (21.23) | SSRI + SNRI + AP | 21 (24.42) | SNRI + AP | 20 (95.24) |
|  |  |  | SSRI + AP + MS | 20 (23.26) | AP + MS | 13 (65.00) | |
|  |  |  | SSRI + SSRI + AP | 16 (18.60) | SSRI + AP | 15 (93.75) | |
2 | SSRI | 71 (17.53) | SSRI + SNRI | 17 (23.94) | SNRI | 15 (88.24) | |
|  |  |  | SSRI + AP | 14 (19.72) | SSRI + AP + MS | 6 (42.86) | |
|  |  |  |  |  | SNRI + AP | 3 (21.43) | |
|  |  |  | SSRI + SSRI | 11 (15.49) | SSRI | 9 (81.82) | |
3 | SSRI + NaSSA | 30 (7.41) | SSRI + NaSSA + AP | 7 (23.33) | SSRI + AP | 3 (42.86) | |
|  |  |  | SSRI + NaSSA + SNRI | 6 (20.00) | NaSSA + SNRI | 4 (66.67) | |
4 | SNRI + AP | 26 (6.42) | SSRI + SNRI + AP | 8 (30.77) | SSRI + AP | 6 (75.00) | |
|  |  |  | SNRI + AP + MS | 6 (23.08) | AP + MS | 4 (66.67) | |
5 | SNRI | 22 (5.43) | SNRI + AP | 7 (31.82) | SSRI + SNRI + AP | 1 (14.29) | |
|  |  |  |  |  | SSRI + AP + MS | 1 (14.29) | |
|  |  |  | SSRI + SNRI | 5 (22.73) | SSRI | 3 (60.00) | |
5 | NaSSA | 22 (5.43) | SSRI + NaSSA | 9 (40.91) | SSRI | 7 (77.78) | |
|  |  |  | NaSSA + SNRI | 6 (27.27) | SNRI | 3 (50.00) | |