Table 2 Estimates of the causal effect of different psychiatric disorders on thyroid cancer incidence
Exposure | Outcome | IVW (fixed-effect) | MR–Egger | Weighted median | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR (95% CI) | P value | Cochran Q | P value | OR (95% CI) | P value | Cochran Q | P value | MR–Egger intercept | P value | OR (95% CI) | P value | ||
Major depressive disease | Thyroid cancer | 3.956 (1.177–13.299) | 0.026 | 22.594 | 0.601 | 76.975 (0.008-766576.333) | 0.364 | 22.187 | 0.568 | -0.087 | 0.530 | 5.563 (0.998–31.008) | 0.050 |
Schizophrenia | Thyroid cancer | 1.532 (1.123–2.088) | 0.007 | 112.947 | 0.404 | 1.867 (0.438–7.964) | 0.401 | 112.870 | 0.381 | -0.012 | 0.785 | 1.599 (1.014–2.521) | 0.043 |
Bipolar disorder | Thyroid cancer | 0.919 (0.460–1.836) | 0.811 | 6.246 | 0.620 | 155.530 (1.613-14998.511) | 0.067 | 1.287 | 0.989 | -0.477 | 0.061 | 1.003 (0.393–2.559) | 0.996 |