Table 2 Comparison of serum cytokines between MDD patients without anxiety and MDD patients with anxiety

IL-1α (IL-1F1)

2.24 (1.42, 4.30)

2.74 (1.81, 4.68)

-0.887

0.375

1.156

IL-1β (IL-1F2)

6.79 (6.34, 10.39)

6.34 (4.77, 8.23)

-0.842

0.400

1.057

IL-1RA (IL-1F3)

956.58 ± 90.51

917.24 ± 79.09

0.323

0.748

0.954

IL-2

31.63 ± 4.86

27.24 ± 4.99

0.795

0.430

0.936

IL-3

26.53 (23.86, 26.53)

26.53 (23.86, 29.36)

-0.486

0.627

0.859

IL-4

27.82 (9.99, 60.43)

23.17 (6.95, 37.86)

-0.980

0.327

1.210

IL-5

2.04 (1.45, 2.41)

2.04 (1.45, 2.04)

-0.157

0.875

0.981

IL-6

5.43 (1.75, 12.42)

3.43 (2.20 12.83)

-0.029

0.977

0.977

IL-7

10.90 ± 1.29

9.98 ± 1.07

0.551

0.584

0.864

IL-8 (CXCL8)

513.66 ± 102.12

428.50 ± 72.05

0.702

0.486

0.856

IL-10

2.80 (0.97, 6.22)

1.54 (1.54, 2.80)

-1.317

0.118

1.092

IL-12 (IL-23 p40)

226.13 ± 10.62

221.69 ± 11.16

0.276

0.784

0.907

IL-12 p70

25.63 ± 2.86

23.33 ± 2.39

0.620

0.538

0.829

IL-13

243.20 ± 11.21

242.06 ± 7.85

0.086

0.932

0.958

IL-15

2.86 (1.54, 4.82)

3.60 (2.34 6.12)

-0.983

0.326

1.340

IL-16

178.42 ± 16.88

172.52 ± 11.49

0.300

0.766

0.914

IL-17 C

12.61 ± 1.07

10.00 ± 0.72

2.111

0.040

1.480

IL-27

296.95 ± 20.63

301.21 ± 24.85

-0.127

0.900

0.951

IL-31

26.20 (21.40, 31.81)

26.20 (21.40, 31.81)

-0.130

0.897

0.976

CCL3 (MIP-1α)

608.56 ± 111.68

515.78 ± 71.89

0.737

0.465

0.906

CCL4 (MIP-1β)

445.93 ± 69.59

421.01 ± 44.93

0.315

0.754

0.930

CCL11 (Eotaxin)

127.97 ± 12.44

106.11 ± 8.07

1.539

0.130

0.802

CCL17 (TRAC)

359.01 ± 28.98

285.69 ± 21.99

2.054

0.045

0.833

CCL26 (Eotaxin-3)

14.91 ± 1.24

13.66 ± 0.98

0.798

0.429

0.992

CXCL10 (IP-10/CRG-2)

18.66 ± 1.19

19.59 ± 1.18

-0.538

0.593

0.844

VEGF

110.95 ± 12.61

89.95 ± 6.62

1.595

0.117

1.443

VEGF-C

1644.09 ± 117.19

1778.98 ± 97.67

-0.883

0.381

1.084

VEGFR1 (Flt1)

163.04 ± 12.86

147.05 ± 9.11

1.044

0.301

1.591

TNF-α

4.46 (2.87, 6.57)

3.33 (2.87, 5.34)

-0.722

0.471

0.871

TNF-β (Lymphotoxin)

2.76 ± 0.21

2.58 ± 0.15

0.683

0.498

0.838

Tie-2

16038.61 ± 1342.56

14912.87 ± 1150.79

0.638

0.526

0.846

IFN-γ

14.92 (11.85, 23.83)

14.92 (11.85 18.40)

-0.834

0.404

0.997

GM-CSF

3.94 ± 0.41

3.21 ± 0.26

1.569

0.123

0.910

FGF basic (FGF2/bFGF)

10.25 ± 1.46

9.53 ± 1.17

0.387

0.700

0.925

TSLP

1.14 ± 0.07

1.06 ± 0.05

1.032

0.307

1.420

ICAM-1 (CD54)

233,586 (71,458, 561,730)

236,650 (186,478, 599,410)

-0.922

0.357

1.201

PIGF

2.16 ± 0.16

2.33 ± 0.14

-0.781

0.438

0.900