Table 4 Mean dose-adjusted plasma concentrations and metabolic ratios in the different CYP2D6 phenotypes (n = 68)
|  | IMs (n = 38) | NMs (n = 30) | Statistics | p |
|---|---|---|---|---|
RIP (ng/ml) | 14.23 (10.79) | 4.75 (3.93) | Z=-4.190 | < 0.001 |
9-OH-RIP (ng/ml) | 37.43 (18.82) | 35.74 (14.55) | t = 407 | 0.685 |
Active moiety (ng/ml) | 51.67 (24.62) | 40.49 (13.76) | Z=-1.686 | 0.092 |
RIP/9-OH-RIP | 0.44 (0.44) | 0.20 (0.25) | t = 2.703 | 0.009 |
RIP/D (ng/ml/mg) | 3.64 (3.45) | 1.08 (1.09) | Z=-4.238 | < 0.001 |
9-OH-RIP/D (ng/ml/mg) | 8.89 (5.01) | 7.20 (2.68) | Z=-1.204 | 0.092 |
C/D (ng/ml/mg) | 12.53 (7.07) | 8.28 (2.93) | Z=-2.940 | 0.003 |