| Prescribing Indicator | Median Score | 75th Centile Value |
---|---|---|---|
1 | Consider adjunctive metformin, unless contraindicated, in people with SMI (Severe Mental Illness) who are prescribed clozapine or olanzapine and who have demonstrated early weight gain* *early weight gain is defined as 5% of body weight in the first month of treatment and is a predictor of long-term weight gain (> 15% over 3 months) | 1 | 2 |
2 | For people with dementia who have a history of cerebrovascular disease or who have evidence on neurological examination or neuroimaging of cerebrovascular disease consider low-dose aspirin eg. 75 mg daily to prevent or lessen further cognitive decline, unless contraindicated | 2 | 2 |
3 | Perform VTE risk assessment for all adults with SMI admitted to the secondary care setting with reduced mobility | 1 | 2 |
4 | Where gastroprotection is indicated, low dose proton pump inhibitors (PPIs) are the preferred treatment choice in adults with SMI who are prescribed agents with a high anticholinergic cognitive burden (ACB). This is because H2 receptor antagonists may increase the ACB and could increase the risk of cognitive impairment | 1.5 | 2 |
5 | Tobacco smoking can alter the pharmacokinetics of psychotropic medications: For people with SMI who are taking TCA’s, mirtazapine, haloperidol and benzodiazepines, do not reduce the dose of the psychotropic drug but instead, monitor for adverse effects | 2 | 2 |
 | Carry out a fracture risk assessment using a validated tool such as QFracture or Frax to determine the need for antiosteoporosis therapy for: |  |  |
6 | i.Adults over 50Â years who are prescribed sodium valproate, carbamazepine, primidone, or phenytoin because these agents are associated with reduced bone mineral density, osteopenia, osteoporosis and increased risk of fractures | 2 | 2 |
7 | ii.Adults < 50 years old on oral steroids (prednisolone > 7.5 mg/day or equivalent for ≥ 3 months) | 2 | 2 |
8 | In individuals with inadequate light exposure or at risk of vitamin D deficiency (eg. nursing home residents, African, African-Caribbean and South Asian populations), supplementation with 10 µg/day of vitamin D should be considered | 2 | 2 |
9 | Adults who consume more than 3.5 units of alcohol per day should be advised to reduce their alcohol intake to nationally recommended levels (< 14 units/week in both men and women) | 1 | 1.75 |