Type of outcome | Instrument |  | ICPT (N = 59) |  |  |  | CAU (N = 34) |  |
---|---|---|---|---|---|---|---|---|
Quality of life | Patient-rated | Mean (SD) | Change from baseline per 6 months estimate, ([95%-CI]) | p-value |  | Mean (SD) | Change from baseline per 6 months estimate, ([95%-CI]) | p-value |
 | MANSA |  | 0.082, ([0.023,0.142]) | 0.007 | MANSA |  | 0.025, ([−0.050,0.101]) | 0.511 |
 | Baseline | 4.1(0.8) | Baseline | 4.8(0.8) | ||||
 | 6 months | 3.9(0.7) | 6 months | 4.6(1.1) | ||||
 | 12 months | 4.4(0.8) | 12 months | 4.6(0.8) | ||||
 | 18 months | 4.2(0.7) | 18 months | 4.8(0.8) | ||||
Clinician-perceived patient difficulty | Clinician-rated | Clinician-rated | ||||||
 | DDPRQ |  | −0.473, ([− 0.879,-0.050]) | 0.029 | DDPRQ |  | −1.297, ([−1.881,-0.713]) | < 0.001 |
 | Baseline | 23.8(4.8) | Baseline | 22.9(4.7) | ||||
 | 6 months | 24.2(3.9) | 6 months | 20.6(4.9) | ||||
 | 12 months | 21.7 (4.5) | 12 months | 21.7(4.6) | ||||
 | 18 months | 22.3(3.7) | 18 months | 19.2(5.4) | ||||
 | PD |  | − 0.21, ([− 0.361,-0.074]) | 0.003 | PD |  | −0.311, ([− 0.507,-0.114]) | 0.002 |
 | Baseline | 3.3(1.3) | Baseline | 3.0(1.7) | ||||
 | 6 months | 3.2(1.6) | 6 months | 1.8(1.1) | ||||
 | 12 months | 2.4(1.3) | 12 months | 2.3(1.6) | ||||
 | 18 months | 2.7(1.3) | 18 months | 2.3(1.2) | ||||
General Mental Health | Patient-rated | Patient-rated | ||||||
 | HONOS |  | −1.056, ([− 1.480,-0.632]) | < 0.001 | HONOS |  | − 1.180, ([− 1.763,-0.597]) | < 0.001 |
 | Baseline | 12.1(4.6) | Baseline | 10.5(5.4) | ||||
 | 6 months | 9.7(3.9) | 6 months | 8.9(4.8) | ||||
 | 12 months | 8.1(4.6) | 12 months | 7.8(5.4) | ||||
 | 18 months | 9.1(4.9) | 18 months | 8.4(4.4) | ||||
Treatment | Patient-rated | Patient-rated | ||||||
 | OQ45 |  | − 0.049, ([− 0.084,-0.015]) | 0.005 | OQ45 |  | −0.042, ([− 0.086,0.002]) | 0.065 |
 | Baseline | 81.7(23.7) | Baseline | 65.1(27.5) | ||||
 | 6 months | 83.2(22.5) | 6 months | 65.0(31.3) | ||||
 | 12 months | 75.4(24.8) | 12 months | 64.1(22.2) | ||||
 | 18 months | 72.7(24.5) | 18 months | 59.7(26.8) | ||||
Illness management and Recovery | Patient-rated | Patient-rated | ||||||
 | IMR-Patient |  | 0.037, ([0.002,0.073]) | 0.036 | IMR-Patient |  | − 0.023, ([− 0.073,0.027]) | 0.369 |
 | Baseline | 3.2(0.4) | Baseline | 3.3(0.4) | ||||
 | 6 months | 3.3(0.4) | 6 months | 3.3(0.4) | ||||
 | 12 months | 3.4(0,4) | 12 months | 3.4(0.4) | ||||
 | 18 months | 3.3(0.4) | 18 months | 3.3(0.3) | ||||
 | Clinician-rated | Clinician-rated | ||||||
 | IMR Clinician |  | 0.130, ([0.078,0.182]) | < 0.001 | IMR-Clinician |  | 0.124, ([0.051,0.197]) | 0.001 |
 | Baseline | 3.1(0.3) | Baseline | 3.3(0.4) | ||||
 | 6 months | 3.3(0.7) | 6 months | 3.2(0.6) | ||||
 | 12 months | 3.5(0.3) | 12 months | 3.5(0.4) | ||||
 | 18 months | 3.4(0.5) | 18 months | 3.5(0.4) | ||||
Therapeutic relationship | Patient-rated | Patient-rated | ||||||
 | STAR-Patient |  | 0.121, ([− 0.458,0.701]) | 0.681 | STAR-Patient |  | − 0.499, ([−1.223,0.225]) | 0.176 |
 | Baseline | 37.5(6.2) | Baseline | 38.9(6.3) | ||||
 | 6 months | 37.2(5.9) | 6 months | 38.4(5.5) | ||||
 | 12 months | 38.7(5.6) | 12 months | 36.3(10.4) | ||||
 | 18 months | 38.2(5.1) | 18 months | 38.2(7.0) | ||||
 | Clinician-rated | Clinician-rated | ||||||
 | STAR-Patient |  | 0.094, ([−0.369,0.557]) | 0.689 | STAR-Patient |  | 0.137, ([− 0.049,0.684]) | 0.620 |
 | Baseline | 37.5(6.2) | Baseline | 39.0(3.9) | ||||
 | 6 months | 37.2(5.9) | 6 months | 39.7(3.2) | ||||
 | 12 months | 38.7(5.6) | 12 months | 39.7(4.3) | ||||
 | 18 months | 38.2(5.1) | 18 months | 41.3(3.9) | ||||
Care Needs | Patient-rated | |||||||
 | CANSAS-Patient, unmet needs |  | −0.260, ([− 0.413,-0.108]) | < 0.001 | CANSAS-Patient, unmet needs |  | − 0.424, ([− 0.615,-0.233]) | < 0.001 |
 | Baseline | 2.3(2.6) | Baseline | 1.4(1.7) | ||||
 | 6 months | 1.8(2.2) | 6 months | 0.5(1.0) | ||||
 | 12 months | 1.4(1.9) | 12 months | 0.4(0.8) | ||||
 | 18 months | 1.4(2.0) | 18 months | 0.4(1.1) | ||||
 | Clinician-rated | Clinician-rated | ||||||
 | CANSAS-Clinician unmet needs |  | −0.604, ([− 0.785,-0.422]) | < 0.001 | CANSAS-Clinician unmet needs |  | −0.768, ([− 0.981,-0.555]) | < 0.001 |
 | Baseline | 2.5(2.8) | Baseline | 2.4(2.3) | ||||
 | 6 months | 1.3 (2.0) | 6 months | 0.5(1.2) | ||||
 | 12 months | 0.7(1.4) | 12 months | 0.4(1.1) | ||||
 | 18 months | 0.6(1.4) | 18 months | 0.2(0.7) | ||||
Social Network | Patient-rated | Patient-rated | ||||||
 | SNM, quality of social network |  | 0.024, ([− 0.007,0.045]) | 0.128 | SNM, quality of social network |  | 0.031, ([− 0.011,0.074]) | 0.145 |
 | Baseline | 0.6(0.5) | Baseline | 0.6(0.4) | ||||
 | 6 months | 0.7(0.4) | 6 months | 0.8(0.4) | ||||
 | 12 months | 0.8(0.5) | 12 months | 0.6(0.5) | ||||
 | 18 months | 0.7(0.4) | 18 months | 0.7(0.4) | ||||
 | SNM, quantity of social network |  | − 0.085, ([− 0.156,-0.013]) | 0.020 | SNM, quantity of social network |  | 0.002, ([− 0.087,0.092]) | 0.960 |
 | Baseline | −0.3(1.1) | Baseline | − 0.4(0.9) | ||||
 | 6 months | − 0.6(0.9) | 6 months | − 0.4(1.3) | ||||
 | 12 months | − 0.7(0.8) | 12 months | − 0.6(0.7) | ||||
 | 18 months | − 0.4(0.8) | 18 months | − 0.4(0.9) |