Working memory deficits in schizophrenia are associated with the rs34884856 variant and expression levels of the NR4A2 gene in a sample Mexican population: a case control study

Table 1 Socio-demographic characteristics, clinical data, and genotype distribution of NR4A2 in schizophrenia patients and control group

Characteristics	Schizophrenia group (n = 187)	Control group (n = 227)	P
Age, year (±SD)	35.44(±10.07)	38.33 (±13.17)	0.066^a
Gender, n (%)
Male	111 (59.4)	127 (55.9)
Female	76 (40.6)	100 (44.1)	0.485^b
Education, year (±SD)	10.98 (±3.46)	11.52 (±4.47)	0.295 ^a
Family history of schizophrenia (%)	64 (34.2)	–
Age of onset, year (±SD)	23.16 (±7.62)	–
Disease duration, year (±DS)	12.39(±9.76)	–
Typical antipsychotics, n (%)	64 (34)
SSRI n (%)	17 (9)
rs34884856 promoter variant
Allele n (%)
2C	211 (56)	261 (57)	0.757 ^b
3C	163 (44)	193 (43)
Genotype n (%)
2C/2C	54 (28.9)	72 (31.7)
3C/2C	103 (55.1)	117 (51.5)	0.762 ^b
3C/3C	30 (16.0)	38 (16.7)
HWE (p)	0.14	0.43
rs35479735 intron 6 variant
Allele n (%)
2G	168 (45)	211 (46)	0.656 ^b
3G	206 (55)	243 (54)
Genotype n (%)
2G/2G	32 (17.1)	48 (21.1)
3G/2G	104 (55.6)	115 (50.7)	0.504 ^b
3G/3G	51 (27.3)	64(28.2)
HWE (p)	0.11	0.89

Data are presented as mean ± SD. Underlined allele denotes the minor allele
n Total participants, SD Standard deviation, SSRI Selective serotonin reuptake inhibitors, HWE Hardy-Weinberg Equilibrium, 3C Insertion C, 2C Deletion C, 3G Insertion G, 2G Deletion
^aMann Whitney U test; ^bChi-squared test

ISSN: 1471-244X