A case report of acute hypothermia during initial inpatient clozapine titration with review of current literature on clozapine-induced temperature dysregulations

Table 3 Demographics & Characteristic Features of Clozapine-Induced Hyper- and Hypothermia

Demographics & Characteristic Features	Clozapine-Induced Fever	Clozapine-Induced Hypothermia
Onset	< 1 month appears to be greatest risk, but may occur at any time or with dose increases [24,25,26]
Dose Related	Unlikely, but risk possibly increased with overdose [23, 24]
Titration Related	Possibly (dose increases > 50 mg/week) [27, 28]	Unknown
Concomitant Medication(s) Which May Increase Risk	Valproic acid, additional antipsychotics [28, 29]	Valproic acid, benzodiazepines, additional antipsychotics [24]
Sex Category	Male>female (~ 1.5:1) [24]
Age (years)	Average age ~ 41 (~ 70% are 40+, with ~ 5.4% being 60+) [24, 27]	Average age ~ 46 (~ 63% are 40+, with ~ 25.8% being 60+) [24]
Seen on Rechallenge	Possibly, but uncommon [27, 28]	Unknown

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