How well do elderly patients with major depressive disorder respond to antidepressants: a systematic review and single-group meta-analysis

Table 2 Subgroup analyses (dichotomous moderators)

Moderator	Percentage responders	Lower limit	Upper limit	Q-value for subgroup differences	P-value for subgroup differences
Antidepressant subgroups
SSRI (N = 28)	0.48	0.42	0.54
TCA (N = 15)	0.57	0.50	0.63
SSNRI (N = 9)	0.49	0.37	0.61
α2-Antagonist (N = 6)	0.51	0.41	0.60
SNRI (N = 2)	0.34	0.09	0.74
MAO-Inhibitor (N = 1)	0.75	0.52	0.89
Setting In/ Outpatients
Inpatients (N = 9)	0.46	0.35	0.57	0.39	0.53
Outpatients (N = 37)	0.50	0.44	0.55	0.39	0.53
Sponsorship
Sponsor stated (N = 39)	0.51	0.46	0.57	0.10	0.75
No sponsor stated (N = 29)	0.50	0.45	0.55	0.10	0.75
Presence of a placebo arm
Placebo comparison (N = 15)	0.43	0.37	0.50	6.35	0.01
No Placebo comparison (N = 53)	0.53	0.49	0.57	6.35	0.01
Overall high risk of bias
Studies without overall high risk of bias (N = 65)	0.51	0.47	0.55	0.19	0.67
Studies with overall high risk of bias (N = 3)	0.44	0.18	0.74	0.19	0.67
Data analysis
ITT (N = 53)	0.53	0.49	0.57	1.22	0.27
Completer analyses (N = 5)	0.40	0.21	0.63	1.22	0.27

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