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Table 1 Collected information on central (mental) health outcomes in MOTAR

From: The impact of depression and anxiety treatment on biological aging and metabolic stress: study protocol of the Mood treatment with antidepressants or running (MOTAR) study

 

Instrument

Method

Week 0

Week 6

Week 10

Week 16

Week 52

Primary outcomes

 Biological aging: telomere length, telomerase activity

Fasting blood samples

Blood

X

–

–

X

X

Secondary outcomes

 Biological and general health indicators

  Biomarkers (inflammation, metabolic syndrome)

Fasting blood samples

Blood

X

–

–

X

X

  Gene-expression (RNA)

Fasting blood samples

Blood

X

–

–

X

X

  HPA-axis (cortisol)

2 days of 6 saliva samples

Saliva

X

–

–

X

X

  Oxidative stress

Urine sample

Urine

X

–

–

X

X

  Autonomic nervous system

Electro + impedance cardiography, heart rate variability [81]

ME

X

–

–

X

X

  Blood pressure

Systolic and diastolic BP

ME

X

–

–

X

X

  Body composition

Weight, height, waist+ hip circumfereence

ME

X

–

–

X

X

  Physical condition

Astrand sub max test [82]

ME

X

 

–

X

X

  Muscle strength

Hand grip strength [81]

ME

X

–

–

X

X

  Lung function

Peak expiratory flow [82]

ME

X

–

–

X

X

  Pain

Chronic graded pain scale [83]

Int

X

–

–

X

X

  Somatization

Short somatization questionnaire [84]

SR

X

–

–

X

X

  Disability severity

WHO-DAS II [85]

SR

X

–

–

X

X

 Depressive and anxiety disorders

  Presence of MDD

CIDI: MDD [78]

Int

X

–

–

X

X

  Presence of anxiety dis

CIDI: SocPhob, Agora, GAD, PA [78]

Int

X

–

–

X

X

  Course of symptoms

Life-chart [86]

Int

X

–

–

X

X

  Severity of depression

Inventory of depressive symptoms [87]

SR

X

X

X

X

X

  Severity of anxiety

Beck anxiety index [88] and Fear questionnaire [89]

SR

X

X

X

X

X

  Sleep

Insomnia Rating Scale [90]

Int

X

–

–

X

X

 Descriptive variables, potential confounding covariates and potential mediating variables

  Age, gender, ethnicity

Standard questions

Int

X

–

–

–

–

  Socio-economic status

Education, income, occupation

Int

X

–

–

–

–

  Physical activity

SQUASH questionnaire [91]

SR

X

–

–

X

X

  Smoking

Past + current smoking questions

SR

X

–

–

–

X

  Medication use

Drug container observation

Int

X

–

–

X

X

  Regular alcohol intake

AUDIT questionnaire [92]

SR

X

–

–

–

X

  Somatic diseases

Presence + symptoms of disease

Int

X

–

–

X

X

  Health care

Perceived need of care [93]

Int

X

–

–

X

X

  Work and disability

Tic-P questionnaire [94]

Int

X

–

–

X

X

  Personality

NEO-FFI questionnaire [95]

SR

X

–

–

X

X

  Locus of control

Pearlin & Schooler mastery scale [96]

SR

X

–

–

X

X

  Depression vulnerability

LEIDS-R questionnaire [97]

SR

X

–

–

X

X

  Anxiety vulnerability

Anxiety senstivity index [98]

SR

X

–

–

X

X

  Experimental cognitive task

Implicit association test (IAT) [99]

CT

X

–

 

X

X

  Experimental memory task

Digit Span (WAIS) [100]

Int

X

–

–

X

X

  Important neg + pos life events

Brugha questionnaire [101]

Int

X

–

–

X

X

  Childhood Trauma

Youth Trauma questionnaire [102]

SR

X

–

–

–

–

  Familiy history

Familiy history inventory

Int

X

–

–

–

–

 Neuroimaging assessment (subsample)

  Verbal episodic memory

15-words test [103]

MRI

x

–

–

x

x

  Task-related brain activity

Emotional face matching paradigm and N-back paradigm [104]

MRI

x

–

–

x

x

  Brain network connectivity

Resting state MRI images

MRI

x

–

–

x

x

 Process indicators (intervention adherence)

  Exercise intervention group: Exercise participation and heart rate will be administrated during each session..

   Antidepressant intervention group

Side effect medication questionnaire

Int

–

X

X

X

–

Adherence (pill count)

Int

–

X

X

X

–

  1. SR self-report, Int interview, Blood data collection via fasting blood sample, CT computer task, ME medical examination