Effects of exercise on symptoms of anxiety, cognitive ability and sick leave in patients with anxiety disorders in primary care: study protocol for PHYSBI, a randomized controlled trial

Table 1 Measures, methods and assessment points used in the study

Variable	Measure	Method	T0 Baseline	T1 12 weeks	T2 1 year
Psychiatric diagnosis	M.I.N.I.	Interview	X	X	X
Anxiety symptoms	BAI	Self-report	X	X	X
Depression symptoms	MADRS	Self-report	X	X	X
Psychoactive drugs	Questionnaire	Self-report	X	X	X
Blood pressure	MmHg	Objective assessment	X	X	X
BMI	Kg/m²	Objective assessment	X	X	X
Alcohol use	AUDIT	Self-report	X	X	X
Quality of life	EQ-5D	Self-report	X	X	X
Cognitive function	WAIS-IV (d.s., b.d., m.r.)	Objective assessment	X	X	X
Cognitive function	D-KEFS (d.f.)	Objective assessment	X	X	X
Cardiovascular fitness	Åstrand’s ergometer test	Objective assessment	X	X	X
Muscle strength	One-leg-rising-test	Objective assessment	X	X	X
Sick leave	Questionnaire	Self-report	X	X	X
Hormones/cytokines	S-IGF-1, S-BDNF, S-VEGF, CRP	Blood samples	X	X	X

M.I.N.I. Mini International Neuropsychiatric Interview, BAI Beck Anxiety Inventory, MADRS Montgomery Åsberg Depression Rating Scale, BMI Body mass index, AUDIT Alcohol Use Disorders Identification Test, EQ-5D EuroQoL-5 Dimension Questionnaire, WAIS-IV Wechsler Adult Intelligence Scale, 4th edition, d.s. digit span, b.d. block design, m.r. matrix reasoning, D-KEFS Delis-Kaplan Executive Function System, d.f. design fluency, S-IGF-1 serum insulin-like growth factor 1, S-BDNF serum brain-derived neurotrophic factor, S-VEGF serum vascular endothelial growth factor, CRP high sensitivity C-reactive protein

ISSN: 1471-244X