Table 2 Characteristics of patients stratified by New York Heart Association functional class
Variables | Total | NYHA class I | NYHA class II | NYHA class III-IV | p value |
|---|---|---|---|---|---|
N = 443 | N = 115 | N = 261 | N = 67 | ||
26.0% | 58.9% | 15.1% | |||
Characteristic of patients | |||||
 Age,mean ± SD,y | 63.9 ± 9.8 | 61.3 ± 9.3 | 64.0 ± 9.8 | 68.2 ± 9.5 | <.001 |
 Male,sex,No.(%) | 337(76.1) | 85(73.9) | 199(76.2) | 53(79.1) | 0.73 |
 Body mass index,mean ± SD,kg/m2 | 24.5 ± 3.1 | 24.5± | 24.5 ± 3.0 | 24.6 ± 3.6 | 0.94 |
 Ejection Fraction,mean ± SD,% | 59.3 ± 11.0 | 61.0 ± 8.2 N = 100 | 60.8 ± 12.3 N = 235 | 50.1 ± 16.1 N = 58 | <.001 |
 Nt-ProBNP,median(interquartile),pg/mL | 123(50–382) | 88(37–234) N = 92 | 118(50–309) N = 228 | 733(133–3892) N = 49 | <.001 |
 Creatinine Clearance,mean ± SD,ml/min | 65.5 ± 21.7 | 69.5 ± 18.2 | 67.0 ± 22.2 | 53.0 ± 21.0 | <.001 |
Type of angina pectoris,No.(%) | 0.24 | ||||
 Unstable angina pectoris | 256(57.8) | 65(56.5) | 158(60.5) | 33(49.3) |  |
 Stable angina pectoris | 187(42.2) | 50(43.5) | 103(39.5) | 34(50.7) |  |
Severity of coronary artery stenosis,No.(%) | <.001 | ||||
 1 | 93(21.0) | 40(34.8) | 46(17.6) | 7(10.4) |  |
 2 | 82(18.5) | 19(16.5) | 54(20.7) | 9(13.4) |  |
 3 | 268(60.5) | 56(48.7) | 161(61.7) | 51(76.1) |  |
Mood symptoms | |||||
 Depression severity,No.(%) | <.001 | ||||
  Non-depressed | 271(61.2) | 79(68.7) | 169(64.8) | 23(34.3) |  |
  Mild depression symptom | 123(27.8) | 27(23.5) | 66(25.3) | 30(44.8) |  |
  Moderate or severe depression symptom | 49(11.1) | 9(7.8) | 26(10.0) | 14(20.9) |  |
 Somatic depressive symptom score,mean(SD) | 3.05(2.87) | 2.81(2.64) | 2.79(2.76) | 4.48(3.28) | <.001 |
 Cognitive depressive symptom score,mean(SD) | 1.36(1.98) | 1.21(1.94) | 1.20(1.76) | 2.24(2.58) | <.001 |
 Anxiety severity,No.(%) | 0.99 | ||||
  Non-anxious | 316(71.3) | 80(69.6) | 186(71.3) | 50(74.6) |  |
  Mild anxiety symptom | 103(23.3) | 30(26.1) | 62(23.8) | 11(16.4) |  |
  Moderate or severe anxiety symptom | 24(5.4) | 5(4.3) | 13(5.0) | 6(9.0) |  |
Social economic factors | |||||
 Education,No.(%) | 0.83 | ||||
  less than 6 years | 115(26.0) | 26(22.6) | 69(26.4) | 20(29.9) |  |
  7–9 years | 126(28.4) | 33(28.7) | 75(28.7) | 18(26.9) |  |
  10–12 years | 97(21.9) | 29(25.2) | 52(19.9) | 16(23.9) |  |
  more than 12 years | 105(23.7) | 27(23.5) | 65(24.9) | 13(19.4) |  |
 Marriage,No.(%) | 0.57 | ||||
  Married | 412(93.0) | 109(94.8) | 240(92.0) | 63(94.0) |  |
  Divorced or Widowed or Single | 31(7.0) | 6(5.2) | 21(8.0) | 4(6.0) |  |
Medical history,No.(%) | |||||
 Hypertension | 276(62.3) | 56(48.7) | 173(44.8) | 45(67.2) | .003 |
 Diabetes mellitus | 154(34.8) | 28(24.3) | 90(34.5) | 36(53.7) | <.001 |
 Prior PCI | 167(37.7) | 42(36.5) | 93(35.6) | 34(50.7) | .069 |
 History of antidepressant treatment | 17(3.8) | 4(3.5) | 9(3.4) | 4(6.0) | 0.61 |
Medication use,No.(%) | |||||
 ACEI or ARB | 317(71.6) | 76(66.1) | 192(73.6) | 49(73.1) | 0.32 |
 β blocker | 384(86.7) | 95(82.6) | 232(88.9) | 57(85.1) | 0.23 |
 Aldosterone receptor antagonist | 42(9.5) | 2(1.7) | 14(5.4) | 26(38.8) | <.001 |
 Loop diuretic | 47(10.6) | 2(1.7) | 16(6.1) | 29(43.3) | <.001 |
 Anticoagulant | 20(4.5) | 3(2.6) | 12(4.6) | 5(7.5) | 0.31 |
 Antidepressant | 9(2.0) | 1(0.9) | 6(2.3) | 2(3.0) | 0.55 |