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Table 1 Number and rates of suicides involving single-drugs or single and multiple (first-listed) drugs in England and of individuals prescribed each medication, in individuals aged 15 years and over (2005–2012)

From: Relative toxicity of mood stabilisers and antipsychotics: case fatality and fatal toxicity associated with self-poisoning

 

Single-drug deaths in England, total n

Single-drug deaths in England, death rate per 100,000 person-years (95% CI)

Single and first listed drug deaths in England, total n

Single and first listed drug deaths in England, Death rate per 100,000 person-years (95% CI)

Prescriptions, average number per year

Prescription rate per 100,000 person-years (95% CI)

Non-fatal self-poisonings in three centres, average number per year

Self-poisoning rate per 100,000, per 100,000 person-years (95% CI)

Mood Stabilisers

 Lithium

6

0.002 (0.001–0.004)

10

0.003 (0.001–0.005)

4956

107.24 (106.18–108.30)

12

1.64 (1.32–2.01)

 Sodium valproate

15

0.004 (0.002–0.007)

18

0.005 (0.003–0.008)

15,433

333.97 (332.11–335.84)

32

4.45 (3.92–5.03)

 Carbamazepine

33

0.010 (0.007–0.014)

56

0.016 (0.012–0.021)

18,836

407.62 (405.56–409.68)

28

3.87 (3.88–4.42)

 Lamotrigine

5

0.001 (0.00–0.003)

12

0.004 (0.002–0.006)

7635

165.22 (163.91–166.54)

15

2.02 (1.67–2.43)

 Total

59

 

96

 

46,860

 

87

 

Antipsychotics

 Chlorpromazine

12

0.004 (0.002–0.006)

19

0.006 (0.003–0.009)

3760

81.37 (80.46–82.30)

25

3.44 (2.97–3.95)

 Risperidone

1

0.000 (0.00–0.002)

2

0.001 (0.00–0.002)

8302

179.65 (178.29–181.03)

34

4.69 (4.15–5.29)

 Quetiapine

40

0.012 (0.008–0.016)

65

0.019 (0.015–0.024)

9971

215.78 (214.28–217.28)

73

10.20 (9.39–11.07)

 Olanzapine

55

0.016 (0.012–0.021)

78

0.023 (0.018–0.029)

10,568

228.70 (227.16–230.25)

61

8.55 (7.81–9.34)

 Clozapine

35

0.010 (0.007–0.014)

40

0.012 (0.008–0.016)

157

3.39 (3.21–3.59)

4

0.54 (0.36–0.77)

 Total

143

 

204

 

32,758

 

197

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