Physical fitness and dementia risk in the very old: a study of the Lothian Birth Cohort 1921

BMC Psychiatry

Table 2 Regression Results

	Odds/ Hazard Ratios (95% CI) for Probable Dementia
	Logistic Regression Model 1	Cox Regression Model 1	Logistic Regression Model 2	Cox Regression Model 2
	Odds Ratios (95% CI)	Hazard Ratios (95% CI)	Odds Ratios (95% CI)	Hazard Ratios (95% CI)
	(n = 425)	(n = 425)	(n = 416)	(n = 416)
Sex (female)	0.77 (0.31, 1.85)	1.26 (0.56, 2.83)	0.86 (0.34, 2.11)	1.42 (0.63, 3.23)
Age (days)	1.00 (1.00, 1.00)	1.00 (1.00, 1.00)	1.00 (1.00, 1.00)	1.00 (1.00, 1.00)
Height (centimetres)	0.96 (0.92, 1.00)	0.97 (0.94, 1.01)	0.95 (0.91, 1.00)	0.97 (0.93, 1.01)
APOE ɛ4 carrier	2.47 (1.49, 4.08)	2.72 (1.78, 4.14)	2.52 (1.50, 4.22)	2.85 (1.85, 4.41)
Age 11 IQ	1.00 (0.98, 1.02)	0.99 (0.98, 1.01)	1.00 (0.98, 1.02)	1.00 (0.98, 1.01)
History of hypertension	0.64 (0.38, 1.05)	0.79 (0.51, 1.23)	0.64 (0.38, 1.06)	0.78 (0.50, 1.22)
Smoker (ever)	0.63 (0.38, 1.04)	0.92 (0.60, 1.40)	0.62 (0.37, 1.03)	0.94 (0.61, 1.45)
FEV₁ (l/s)	2.05 (1.15, 3.75)	1.43 (0.82, 2.48)	1.93 (1.07, 3.57)	1.30 (0.74, 2.30)
6 m walk time (s)	0.93 (0.79, 1.07)	0.99 (0.87, 1.13)	0.94 (0.79, 1.08)	0.99 (0.87, 1.13)
Grip strength (kg)	1.00 (0.96, 1.05)	0.98 (0.94, 1.02)	1.01 (0.96, 1.05)	0.98 (0.94, 1.02)
History of cardiovascular or cerebrovascular disease	–	–	1.08 (0.61, 1.86)	1.14 (0.72, 1.81)
History of diabetes	–	–	0.86 (0.19, 2.88)	1.39 (0.41, 4.66)

Logistic regression model 1 and Cox regression model 1: included FEV₁, grip strength, 6-m walk time, APOE ɛ4 carrier status, height, age, sex, history of hypertension, smoking status and age 11 IQ, with the development of probable dementia as the outcome. Logistic regression model 2 and Cox regression model 2: as logistic regression model 1 plus history of cardiovascular or cerebrovascular disease and history of diabetes. Results for Cox regressions show the hazard ratios and 95% confidence intervals. Statistically significant results are italicized

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