Do some anxiety disorders belong to the prodrome of bipolar disorder? A clinical study combining retrospective and prospective methods to analyse the relationship between anxiety disorder and bipolar disorder from the perspective of biorhythms

Table 11 Differences in inflammatory cytokine levels among the BD, atypical BD and simple anxiety groups

Variables	BD (n = 48) Mean ± SD	Atypical (n = 63) Mean ± SD	Anxiety (n = 111) Mean ± SD	F
IL-6	3.52 ± 3.54	6.42 ± 4.19^a	2.53 ± 2.72^b	9.022^***
IL-8	27.92 ± 55.31	22.86 ± 40.00	24.76 ± 78.82	0.025
IL-10	4.66 ± 0.55	3.49 ± 0.86^c	4.43 ± 0.86^d	12.193^***
TNF	7.69 ± 3.13	10.89 ± 7.76^e	5.67 ± 2.08^f	8.632^***
CRP	2.84 ± 3.38	4.44 ± 3.83^g	2.62 ± 2.85^h	8.708^***

***P < 0.001
^aThe atypical group was significantly higher than the BD group (P = 0.007). ^bThe atypical group was significantly higher than the anxiety group (P = 0.000). ^cThe atypical group was significantly lower than the BD group (P = 0.000). ^dThe atypical group was significantly lower than the anxiety group (P = 0.000). ^eThe atypical group was significantly higher than the BD group (P = 0.035). ^fThe atypical group was significantly higher than the anxiety group (P = 0.000). ^gThe atypical group was significantly higher than the BD group (P = 0.042). ^hThe atypical group was significantly higher than the anxiety group (P = 0.000)

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