Fig. 4

a Healthcare resource utilization PPPY during the study period - treatment pattern-level. Pattern 1a: Discontinuation→Remained Untreated Pattern 1b: Discontinuation→Resumption→Discontinuation→Resumption Pattern 1c: Discontinuation→Resumption→Discontinuation→Remained Untreated Pattern 2a: Escalation→Discontinuation→Remained Untreated Pattern 2b: Escalation→Discontinuation→Resumption→Discontinuation Pattern 2c: Escalation→Persistence Pattern 3a: Switch→Discontinuation→Remained Untreated Pattern 3b: Switch→Discontinuation→Resumption→Discontinuation Pattern 3c: Switch→Escalation→Discontinuation→Resumption.[1] Data on HCRU are presented only for the three most prevalent patterns within each cohort that comprised more than 5% of the analysis sub-sample (decided a priori). [2] Percentage within each bar represents proportion of days with mental health-related medical visits. b Total healthcare costs PPPY during the study period - treatment pattern-level. Pattern 1a: Discontinuation→Remained Untreated Pattern 1b: Discontinuation→Resumption→Discontinuation→Resumption Pattern 1c: Discontinuation→Resumption→Discontinuation→Remained Untreated Pattern 2a: Escalation→Discontinuation→Remained Untreated Pattern 2b: Escalation→Discontinuation→Resumption→Discontinuation Pattern 2c: Escalation→Persistence Pattern 3a: Switch→Discontinuation→Remained Untreated Pattern 3b: Switch→Discontinuation→Resumption→Discontinuation Pattern 3c: Switch→Escalation→Discontinuation→Resumption [1] Data on costs are presented only for the three most prevalent patterns within each cohort that comprised more than 5% of the analysis sub-sample (decided a priori) [2]. Percentages within each bar represent proportions of mental health-related medical costs and MDD-related pharmacy costs