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Table 3 Association between cardiac function parameters and Torsades de Point (TdP) risk category of antipsychotics

From: Clinicians’ adherence to clinical practice guidelines for cardiac function monitoring during antipsychotic treatment: a retrospective report on 434 patients with severe mental illness

 

AP Torsades de Point risk category, N (%)

  

Monitoring parameters

A

B

C

χ 2

P-value

Presence of ECG testing before AP treatment

48 (29.6)

229 (20.0)

3 (1.1)

12.9

0.002

Presence of ECG testing during AP treatment

46 (28.4)

375 (32.8)

16 (38.1)

1.9

0.3

Presence of electrolytes levels before AP treatment

47 (29.0)

246 (21.5)

2 (4.8)

12.1

0.002

Presence of electrolytes levels during AP treatment

51 (31.5)

358 (31.3)

18 (42.9)

2.5

0.3

Presence of personal history of pre-existing cardiac disease

5 (3.1)

57 (5.0)

4 (9.5)

3.1

0.2

Number of cardiac function parameters tested

 0

63 (38.9)

519 (45.4)

20 (47.6)

10.3a

0.41a

 1

27 (16.7)

190 (16.6)

5 (11.9)

 2

55 (34.0)

298 (26.0)

13 (31.0)

 3

8 (4.9)

73 (6.4)

4 (9.5)

 4

9 (5.6)

56 (4.9)

0 (0.0)

 5

0 (0.0)

8 (0.0)

0 (0.0)

  1. Category A: drugs with known risk of inducing TdP
  2. Category B: drugs with possible risk of inducing TdP
  3. Category C: drugs with conditional risk of TdP
  4. AP antipsychotic
  5. ECG electrocardiogram
  6. a χ 21000 sample bootstrap