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Table 2 Characteristics of patients with postoperative delirium according to the anesthetic methods

From: A personality trait contributes to the occurrence of postoperative delirium: a prospective study

 

General anesthesia (n = 19)

Regional anesthesia (n = 21)

P

Occurrence rate, delirium No./total No.

19/47

21/31

0.02a

Number of occurrence, No. (%)

  

0.06c

 POD 1

5 (26.4)

9 (42.8)

 

 POD 2

3 (15.8)

6 (28.6)

 

 POD 3

4 (21.1)

4 (19.0)

 

 POD 4

5 (26.3)

1 (4.8)

 

 POD 5

2 (10.5)

1 (4.8)

 

 POD 6

0 (0.0)

0 (0.0)

 

 POD 7

0 (0.0)

0 (0.0)

 

Onset day, median (min ~ max)

3 (1 ~ 5)

2 (1 ~ 5)

0.07d

Days of duration, median (min ~ max)

4 (2 ~ 13)

3 (2 ~ 33)

0.39d

Severity: K-DRS scores on the onset day, mean (SD)

 Total

19.8 (4.7)

18.3 (5.0)

0.34e

 Cognitive

10.8 (2.9)

9.5 (3.2)

0.18e

 Non-cognitive

8.9 (2.5)

8.8 (2.8)

0.87e

Difference in MMSE scores: the onset day minus pre-op day, median (min ~ max)

-6.5 (-25 ~ -3)

-4 (-21 ~ -1)

0.45d

Days of hospitalization, median (min ~ max)

11 (7 ~ 36)

9 (7 ~ 45)

0.39d

Preoperative comorbidity, No. (%)

 COPD

0 (0.0)

0 (0.0)

-

 Cerebrovascular disease

4 (21.1)

0 (0.0)

0.04b

 CABG/MI/CAD

4 (21.1)

3 (14.3)

0.69b

 Chronic renal insufficiency

0 (0.0)

0 (0.0)

-

Preoperative medication, No. (%)

 Opiates

0 (0.0)

0 (0.0)

-

 Benzodiazepines

3 (15.8)

5 (23.8)

0.70b

 Antidepressants

6 (31.6)

3 (14.3)

0.27b

 Anticholinergics

2 (10.5)

3 (14.3)

0.72b

 Other psychotics

2 (10.5)

1 (4.8)

0.60b

ASA PS, No. (%)

  

0.80c

 2

3 (15.8)

4 (19.0)

 

 3

15 (78.9)

16 (76.2)

 

 4

1 (5.3)

1 (4.8)

 

Anesthetic drugs

 Propofol dose, median (min ~ max), mcg/kg/min

11.7 (4.5 ~ 33.3)

-

-

 Fentanyl use, No. (%)

19 (100.0)

5 (23.8)

0.00a

 Fentanyl dose, median (min ~ max), mcg/kg

17.5 (0.5 ~ 22.8)

0.00 (0.00 ~ 2.7)

0.00d

 Midazolam use, No. (%)

1 (5.3)

2 (9.5)

0.61b

 Midazolam dose, median (min ~ max), mg/kg

0.00 (0.00 ~ 0.02)

0.00 (0.00 ~ 0.06)

0.83d

  1. Abbreviations: POD postoperative day, IQR interquartile range, COPD chronic obstructive pulmonary disease, CABG coronary artery bypass graft, MI myocardial infarction, CAD coronary artery disease, ASA PS American Society of Anesthesiology Physical Status, K-DRS Korean-Delirium Rating Scale-R-98, SD standard deviation, MMSE mini-mental state examination
  2. aPearson’s chi-square test
  3. bFisher test
  4. cscore test for trend
  5. dMann-Whitney U test
  6. eStudent t-test