Skip to main content

Table 1 Characteristics of the 5 source studies used in these analyses.

From: Maintenance of response with atypical antipsychotics in the treatment of schizophrenia: a post-hoc analysis of 5 double-blind, randomized clinical trials

Primary
reference
Primary
outcomes
Study
drugs
N Mean
modal
dose
(mg/day
[SD])
Study
duration
(weeks)
Diagnoses Other
baseline
inclusion
criteria
Tran [13] Efficacy
Safety
Olanzapine
Risperidone
172
167
17.2 (3.6)
7.2 (2.7)
28 Schz, Schzfm, Schzaff Inpatient and outpatient
Age 18 to 65
BPRS (ext) score ≥ 42
Kinon [14] Negative Symptoms
Functional Outcome
Efficacy
Safety
Olanzapine
Quetiapine
171
175
15.6 (4.3)
455.8 (156.3)
24 Schz, Schzaff Outpatients
Age 18 to 65
Score ≥ 4 on at least 3, or ≥ 5 on at least 2 of the 7 negative symptom items of the PANSS, and ≥ 60 (moderate difficulties) on the GAF.
Breier [17] Efficacy
Safety
Olanzapine
Ziprasidone
277
271
15.3 (4.5)
116.0 (39.9)
28 Schz Inpatient and outpatient
Age 18 to 75
Scores ≥ 42 on the BPRS (ext), ≥ 4 on at least one positive symptom item of the PANSS, and ≥ 4 on the severity of illness subscale of the CGI
Kinon [16] Depressive Symptoms
Efficacy
Safety
Olanzapine
Ziprasidone
202
192
14.2a
110.2a
24 Schz, Schzaff Inpatient and Outpatient
Age 18 to 60
Scores ≥ 16 (mild depression) on the MADRS and ≥ 4 (pervasive feelings of sadness or gloominess) on item 2 (reported sadness) of the MADRS
Kane [15] Efficacy
Safety
Olanzapine
Aripiprazole
281
285
16.7 (2.4)
19.3 (6.8)
28 Schz Initial PANSS Total score of ≥ 75, a minimum score of ≥ 4 on one of the PANSS positive, and a minimum score of 4 on the CGI-S at both visits 1 (screening) and 2 (randomization), with an initial score of ≥ 3 on the CGI-I at visit 2.
  1. Abbreviations: Abbreviations: Schz = Schizophrenia; Schzfm = Schizophreniform Disorder; Schzaff = Schizoaffective Disorder; N = number; NNTs = numbers needed to treat; NNHs = numbers needed to harm; BPRS (ext) = Brief Psychiatric Rating Scale (scored 0–6) extracted from the Positive and Negative Syndrome Scale [7]; PANSS = Positive and Negative Syndrome Scale (scored 1–7) [6]; CGI = Clinical Global Impression Scale [10]; MADRS = Montgomery-Asberg Depression Rating Scale; GAF = Global Assessment of Functioning Scale; SD = standard deviation.
  2. a This study had multiple fixed doses, and therefore, SD is not given.