Table 5 Outcomes in maintenance trials in bipolar mania – efficacy and discontinuations in trials lasting 26 weeks or longer [vs placebo 46. 48, 49 versus active 45, 47]

Relapse

3

135/332

166/257

41

65

0.6 (0.5 to 0.7)

4.2 (3.1 to 6.2)

2

116/255

130/174

45

75

0.6 (0.5 to 0.7)

3.4 (2.6 to 4.9)

2

79/250

96/237

32

41

0.8 (0.6 to 0.98)

11 (5.7 to 250)

3

84/332

79/257

25

31

0.8 (0.6 to 0.98)

18 (7.8 to 18)

2

75/255

68/174

29

39

0.7 (0.6 to 0.97)

10 (5.3 to 200)

3

39/332

74/257

12

29

0.4 (0.3 to 0.6)

5.9 (4.2 to 9.5)

2

33/255

55/174

13

32

0.4 (0.3 to 0.6)

5.4 (3.7 to 9.4)

Discontinuation

3

146/354

116/267

41

43

1.1 (0.9 to 1.3)

not calculated

2

107/276

61/184

39

33

1.3 (1.04 to 1.7)

18 (6.9 to 30)

2

222/342

250/341

65

73

0.9 (0.8 to 0.98)

12 (6.5 to 67)

3

36/354

55/267

10

21

0.6 (0.5 to 0.9)

9.6 (6.2 to 22)

2

17/276

19/184

6

10

0.8 (0.4 to 1.4)

not calculated

2

55/342

62/340

16

18

0.9 (0.6 to 1.2)

not calculated

3

27/354

9/267

8

4

2.4 (1.1 to 5.0)

24 (13 to 160)

2

22/276

8/184

8

5

2.0 (0.9 to 4.5)

not calculated

2

72/342

80/340

21

24

0.9 (0.7 to 1.2)

not calculated