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Table 4 Fixed effects slopes for individual symptoms

From: Time-course of the DSM-5 cannabis withdrawal symptoms in poly-substance abusers

Ā Ā 

Linear

Ā Ā 

Quadratic

Ā Ā Ā 

Symptom:

Ā 

Beta

SE

F-test (1,145)

Beta

SE

F-test (2,144)

Additional substances

Irritability/anger

Linear

0.001

0.001

0.03

0.089

0.03

*4.53

Ā 
Ā 

Squared

Ā Ā Ā 

-0.003

0.001

Ā Ā 

Nervousness

Linear

-0.024

0.008

**9.18

0.025

0.030

**6.08

Ā 
Ā 

Squared

Ā Ā Ā 

-0.014

0.008

Ā Ā 

Insomnia

Linear

-0.036

0.008

***18.76

-0.042

0.031

***9.34

Stimulants +

Ā 

Squared

Ā Ā Ā 

0.000

0.000

Ā Ā 

Loss of appetite

Linear

-0.006

0.006

1.01

-0.029

0.022

1.09

Opioids -

Ā 

Squared

Ā Ā Ā 

0.001

0.001

Ā Ā 

I am restless

Linear

-0.024

0.008

**9.66

0.009

0.029

**5.54

Ā 
Ā 

Squared

Ā Ā Ā 

-0.001

0.001

Ā Ā 

I feel depressed

Linear

-0.016

0.007

*5.37

-0.014

0.027

2.67

Ā 
Ā 

Squared

Ā Ā Ā 

-0.000

0.001

Ā Ā 

Physical symptoms

Linear

-0.015

0.007

*4.73

-0.034

0.027

2.61

Ā 
Ā 

Squared

Ā Ā Ā 

0.001

0.001

Ā Ā 

Vivid dreams

Linear

0.017

0.009

3.35

0.114

0.033

**6.30

Ā 
Ā 

Squared

Ā Ā Ā 

-0.003

0.001

Ā Ā 
  1. All effects controlled for three additional substances (all time-variant variables): Days since last alcohol or benzodiazepine use; Days since last opioid use; Days since last CS use.
  2. Coefficients in bold are significant at pā€‰<ā€‰0.01, coefficients in italics are significant at pā€‰<ā€‰0.05.
  3. F-tests for linear model test that the linear effect of time since last use of cannabis is significant. F-tests for quadratic models test that the combined effect of the linear and the squared effect of days since last use of cannabis is significant. * pā€‰<ā€‰0.05. ** pā€‰<ā€‰0.01. *** pā€‰<ā€‰0.001.