Glucocorticoid receptor mRNA and protein isoform alterations in the orbitofrontal cortex in schizophrenia and bipolar disorder

Table 1 Demographic details of cases used in this study

	Control group	Bipolar disorder group	Schizophrenia group
	(n = 35)	(n = 34)	(n = 35)
Diagnostic subtype	-	BP1 = 27, BP2 = 4, BPNOS = 2, schizoaffective = 1	SCZ(disorganised) = 1, SCZ(paranoid) = 8, SCZ(undifferentiated) = 26
Age (years)	44.2 (31–60)	45.4 (19–64)	42.6 (19–59)
Gender	9 F, 26 M	18 F, 16 M	9 F, 26 M
Hemisphere	16 L, 19R	19 L, 15R	17 L, 18R
pH	6.61 +/− 0.27	6.43 +/− 0.30	6.48 +/− 0.24
PMI (hours)	29.4 +/− 12.9	37.9 +/− 18.6	31.4 +/− 15.5
RIN	7.23 +/− 0.87	7.34 +/− 0.88	7.36 +/− 0.61
Manner of death	natural = 35	natural = 19, suicide = 15	natural = 28, suicide = 7
Age of onset (years)	-	25.3 +/− 9.2	21.3 +/− 6.1
Duration of illness (years)	-	20.2 +/− 9.6	21.3 +/− 10.2
Lifetime antipsychotics (fluphenazine equivalents, mg)	-	10212 +/−22871	85004 +/− 100335
Antidepressant use	yes = 0, no = 35	yes = 19, no = 15	yes = 9, no = 26
Type of antidepressant*	-	SSRI = 9 (fluoxetine = 5) SNRI = 4, SARI = 5, TCA = 6, other = 1	SSRI = 4 (fluoxetine = 2), SNRI = 0, SARI = 2, TCA = 2, other = 2
Smoking around time of death	yes = 9, no = 9, unknown = 17	yes = 15, no = 6, unknown = 13	yes = 23, no = 4, unknown = 8

Demographic details of controls, bipolar disorder cases and schizophrenia cases used in this study. *Note- some individuals took multiple antidepressant medications. Abbreviations: BP1 = bipolar disorder type I, BP2 = bipolar disorder type II, BPNOS = bipolar disorder not otherwise specified, SCZ = schizophrenia, M = male, F = female, L = left, R = right, PMI = post-mortem interval, RIN = RNA integrity number, SSRI = selective serotonin reuptake inhibitor, SNRI = serotonin–norepinephrine reuptake inhibitor, SARI = serotonin antagonist and reuptake inhibitor, TCA = tricyclic antidepressant. Data quoted are mean (range) +/− standard deviation.

ISSN: 1471-244X