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Table 4 Effects of the exclusion criteria on treatment outcome in ROM patients suffering from MDD

From: The generalizability of psychotherapy efficacy trials in major depressive disorder: an analysis of the influence of patient selection in efficacy trials on symptom outcome in daily practice

 

Definition of outcome

Influence on outcome in all patients

Influence on outcome in all patients adjusted1

Influence on outcome in psychotherapy patients

Influence on outcome in psychotherapy patients adjusted1

Current or past abuse or dependence on alcohol

 

ΔMADRS

B = 2.77

B=2.09

-

-

  

95% CI −0.85-6.39

95% CI: -1.50 -5.68

  
  

p=0.13

p=0.25

  
 

Proportion of responders

OR = 2.12

OR 2.36

-

-

  

95% CI 0.80-5.63

95% CI 0.80-7.03

  
  

p=0.13

p=0.13

  
 

Proportion of remitters

OR = 1.95

OR 2.10

-

-

  

95% CI 0.67-5.68

95% CI 0.61-7.27

  
  

p=0.22

p=0.24

  

Current or past abuse or dependence on drugs

 

ΔMADRS

B = − 0.17

B= −1.12

B=3.37

B=3.50

  

95% CI −5.35-5.02

95% CI: -6.04 -3.79

95% CI −1.04 – 7.78

95%CI −8.51-7.85

  

p=0.95

p=0.65

p=0.13

p=0.11

 

Proportion of responders

OR = 0.73

OR 0.70

OR 1.72

OR 1.52

  

95% CI 0.24-2.22

95% CI 0.22-2.15

95% CI 0.17-17.40

95% CI 0.13-17.78

  

p=0.58

p=0.53

p=0.65

p=0.74

 

Proportion of remitters

OR = 0.72

OR 0.77

OR 1.19

OR 0.88

  

95%CI 0.22-2.34

95% CI 0.23-2.54

95%CI 0.12-12.08

95% CI 0.07-10.39

  

p=0.59

p=0.66

p=0.88

p=0.92

Not meeting a minimum baseline severity threshold

 

ΔMADRS

B = 6.39*

B=7.23*

B=3.37

B=3.50

  

95%CI 4.56-8.21 p<0.001

95%CI 5.31-9.14 p<0.001

95% CI −1.04–7.78

95% CI −8.51-7.85

    

p=0.13

p=0.11

 

Proportion of responders

OR = 1.28

OR 1.53

OR 0.90

OR 0.87

  

95% CI 0.83-2.00

95% CI 0.94-2.47

95% CI 0.33-2.45

95% CI 0.31-2.50

  

p=0.27

p=0.09

p=0.84

p=0.80

 

Proportion of remitters

OR = 0.46*

OR 0.53*

OR 0.53

OR 0.49

  

95%CI 0.30-0.70

95% CI 0.33-0.84

95% CI 0.19-1.49

95% CI 0.17-1.45,

  

p<0.001

p=0.01

p=0.23

p=0.20

Previous use of medication or ECT

 

ΔMADRS

B = 1.26

B=1.19

B=7.62*

B=5.49

  

95%CI −0.42-2.95

95%CI −0.45 – 2.83 p=0.15

95%CI 1.94-13.30

95% CI −0.67-11.65

  

p=0.14

 

p<0.01

p=0.08

 

Proportion of responders

OR = 1.47

OR 1.39

OR 6.75

OR 5.46

  

95% CI 1.0-2.17

95% CI 0.93-2.08

95% CI 0.82-55.83

95% CI 0.61-48.68

  

p=0.05

p=0.11

p=0.08

p=0.13

 

Proportion of remitters

OR = 1.53

OR 1.37

OR 4.57

OR 4.04

  

95% CI 1.00-2.34

95% CI 0.88-2.13

95% CI 0.55-38.01

95% CI 0.44-37.26

  

p=0.05

p=0.16

p=0.16

p=0.22

  1. Caption:
  2. * = exclusion of patients who meet this criterion contributes significantly to treatment outcome.
  3. 1 Adjusted= adjusted for age, gender and treatment modality (only in all MDD patients) and for all other exclusion criteria in the model.
  4. B= regression coefficient: amount of additional improvement on the MADRS when patients who meet this exclusion criterion are excluded.
  5. OR= odds ratio, the chance of response or remission when patients who meet this exclusion criterion are excluded in relation to the chance of response or remission when these patients are not excluded.
  6. 95% CI= 95% confidence interval.
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BMC Psychiatry

ISSN: 1471-244X

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