Effect | Ziprasidone Hazard Ratio (95% CI) | Olanzapine Hazard Ratio (95% CI) | Quetiapine Hazard Ratio (95% CI) | Risperidone Hazard Ratio (95% CI) |
---|---|---|---|---|
Age | 0.988 (0.971-1.006) | 0.992 (0.980-1.004) | 0.991 (0.980-1.001) | 0.994 (0.981-1.007) |
Women vs. Men | 1.137 (0.735-1.759) | 1.013 (0.773-1.326) | 1.193 (0.928-1.533) | 0.909 (0.675-1.224) |
Charlson Comorbidity Index | 1.168 (1.027-1.328) | 1.054 (0.912-1.218) | 0.988 (0.855-1.142) | 1.100 (0.968-1.249) |
Prior Psychiatric Hospitalization | 2.805 (1.902-4.136) | 3.051 (2.333-3.990) | 2.777 (2.213-3.485) | 2.551 (1.923-3.385) |
Prior Diabetes | 0.901 (0.414-1.965) | 1.056 (0.550-2.026) | 1.170 (0.704-1.944) | 1.294 (0.738-2.269) |
Prior Hyperlipidemia | 1.255 (0.685-2.299) | 0.834 (0.539-1.289) | 0.828 (0.572-1.199) | 1.162 (0.764-1.769) |
Prior Lipid Test | 0.641 (0.357-1.149) | 0.807 (0.546-1.192) | 1.000 (0.722-1.386) | 1.048 (0.696-1.579) |
Prior Glucose Test | 1.305 (0.858-1.983) | 1.288 (0.963-1.722) | 1.030 (0.801-1.325) | 1.132 (0.819-1.563) |
Pre-index mood stabilizer | ||||
   1 vs. none | 1.624 (0.946-2.789) | 0.735 (0.499-1.085) | 0.849 (0.606-1.188) | 1.310 (0.863-1.988) |
   2 vs. none | 1.241 (0.533-2.890) | 0.387 (0.196-0.764) | 0.646 (0.372-1.122) | 1.737 (0.925-3.263) |
   ≥3 vs. none | 0.833 (0.162-4.287) | 0.434 (0.134-1.408) | 0.705 (0.225-2.207) | 0.304 (0.038-2.416) |
Post-index mood stabilizer | ||||
   Carbamazepine | 2.792 (1.292-6.031) | 2.741 (1.417-5.301) | 1.745 (0.986-3.087) | 1.482 (0.720-3.049) |
   Lamotrigine | 1.204 (0.671-2.161) | 1.765 (1.056-2.952) | 1.058 (0.719-1.555) | 1.273 (0.810-2.002) |
   Lithium | 0.588 (0.298-1.159) | 2.314 (1.509-3.551) | 0.931 (0.626-1.385) | 0.740 (0.452-1.210) |
   Oxcarbazepine | 1.342 (0.655-2.748) | 1.876 (1.034-3.403) | 0.870 (0.519-1.459) | 1.016 (0.584-1.766) |
   Topiramate | 1.006 (0.493-2.051) | 1.753 (0.994-3.091) | 1.336 (0.844-2.117) | 1.052 (0.596-1.855) |
   Valproate | 0.646 (0.341-1.224) | 1.352 (0.889-2.056) | 0.824 (0.561-1.211) | 0.782 (0.504-1.214) |
Year of Index Prescription | 0.937 (0.732-1.199) | 1.032 (0.868-1.228) | 0.963 (0.837-1.109) | 0.959 (0.803-1.146) |
Comparator vs. Aripiprazole | 2.047 (1.388-3.019) | 1.549 (1.098-2.184) | 1.551 (1.139-2.113) | 1.567 (1.124-2.186) |