Association between depression and antibiotic use: analysis of population-based National Health Insurance claims data

Table 2 Comparison of antibiotic use between patients with and without major depressive disorder

	Presence of claim records of prescribed antibiotics		Total annual prescription days of antibiotics per patient with claim records of prescribed antibiotics		Total annual medication costs of antibiotics per patient with claim records of prescribed antibiotics (US dollars^a)
	Per 10,000 patients	Crude OR (95% CI)	Median (Q1, Q3)	p-value	Median (Q1, Q3)	p-value
PS-matched patients without MDD^b (n = 67,800)	7208	- (reference)	9 (4, 18)	–	9.51 (4.25, 20.72)	–
Patients with MDD (n = 16,950)	7881	1.44 (1.38, 1.50)	13 (6, 27)	<.0001^c	13.50 (5.53, 31.14)	< 0.0001^c

^a1 US dollar approximately equals 1200 Korean won
^bPatients without MDD were matched with patients with MDD by propensity score based on demographic characteristics, i.e., age, sex, and the type of National Health Security program enrolled
^cResults of Wilcoxon rank sum tests compared with patients without MDD
CI confidence interval, MDD major depressive disorder, OR odds ratio, PS propensity score, Q1 25th percentile, Q3 75th percentile

ISSN: 1471-244X