| Week 0 (baseline) | Week 8 | Week 16 | Week 24 |  | ||||
---|---|---|---|---|---|---|---|---|---|
Control (N = 36) | Intervention (N = 33) | Control (N = 28) | Intervention (N = 29) | Control (N = 21) | Intervention (N = 27) | Control (N = 24) | Intervention (N = 27) | Total (N = 225) | |
CSDD total | 6.0 (4.0, 11.0) | 11.0* (7.0, 14.0) | 7.0 (4.0, 11.2) | 10.0* (7.0, 13.0) | 5.0 (1.0, 10.0) | 6.0 (5.0, 9.0) | 4.5 (1.8, 7.2) | 8.0* (5.5, 12.5) | 8.0 (4.0, 12.0) |
CSDD Mood-related signs | 2.0 (1.0, 3.0) | 4.0* (2.0, 5.0) | 2.5 (1.0, 4.0) | 3.0 (2.0, 4.0) | 2.0 (0.0, 4.0) | 2.0 (1.0, 3.0) | 2.0 (1.0, 3.0) | 3.0* (2.0, 4.0) | 3.0 (1.0, 4.0) |
CSDD Behavioral disturbance | 1.5 (0.8, 3.0) | 2.0 (1.0, 4.0) | 2.0 (1.0, 3.0) | 3.0 (1.0, 4.0) | 1.0 (0.0, 2.0) | 2.0 (0.5, 3.0) | 0.5 (0.0, 1.2) | 3.0* (1.0, 4.0) | 2.0 (1.0, 3.0) |
CSDD Cyclic functions | 1.0 (0.0, 2.0) | 2.0 (0.0, 4.0) | 2.0 (0.0, 3.0) | 2.0 (1.0, 3.0) | 0.0 (0.0, 2.0) | 1.0 (0.0, 2.5) | 1.0 (0.0, 2.0) | 1.0 (0.0, 2.0) | 1.0 (0.0, 2.0) |
NPI-NH total | 12.5 (5.8, 41.8) | 24.0 (11.0, 42.0) | 17.0 (5.8, 30.0) | 19.0 (9.0, 34.0) | 14.0 (6.0, 34.0) | 13.0 (6.0, 26.2) | 10.0 (5.0, 21.0) | 20.0 (10.0, 28.0) | 16.0 (6.0, 34.0) |
NPI-NH Agitation | 4.5 (0.0, 14.2) | 6.0 (0.0, 12.0) | 6.0 (2.0, 12.5) | 4.0 (2.0, 14.0) | 2.0(0.0, 14.0) | 2.5 (0.2, 5.8) | 4.0 (0.0, 8.0) | 3.0 (1.0, 11.0) | 4.0 (0.0, 12.0) |
NPI-NH Affective symptoms | 0.5 (0.0, 4.0) | 2.0 (0.0, 10.0) | 0.5 (0.0, 4.5) | 1.0 (0.0, 6.0) | 1.0 (0.0, 8.0) | 1.0 (0.0, 4.0) | 0.0 (0.0, 0.0) | 2.0* (0.0, 6.0) | 1.0 (0.0, 6.0) |
NPI-NH Psychosis | 0.0 (0.0, 8.0) | 1.0 (0.0, 8.0) | 0.0 (0.0, 3.0) | 0.0 (0.0, 5.0) | 0.0 (0.0, 4.0) | 0.0 (0.0, 2.0) | 0.0 (0.0, 4.0) | 1.0 (0.0, 4.0) | 0.0 (0.0, 6.0) |