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Global and reflective rumination are related to suicide attempts among patients experiencing major depressive episodes

Abstract

Background

Recent attention has focused on the role of rumination in suicidality, with evidence indicating that rumination may be positively related to suicidal ideation. There remains disagreement on the nature of the relationship between rumination and suicide attempts, especially in major affective disorders. This study was designed to identify whether rumination is a risk factor for attempted suicide.

Methods

A total of 309 patients with major depressive episodes were recruited for this study, including 170 patients with major depression and 139 patients with bipolar disorder. All participants were categorized into two groups based on a series of clinical assessments: suicide attempters (n = 87) and non-suicide attempters (n = 222). Rumination was evaluated with the Ruminative Responses Scale. A binary logistic regression analysis was carried out to evaluate the relationship between rumination and suicide attempts.

Results

Both global ruminative levels and the two subtypes of rumination, brooding and reflection, were significantly higher in the suicide attempters than the non-suicide attempters. After controlling for age, current depression and anxiety symptoms, and episode frequency, it was found that global rumination and reflection (but not brooding) were positively associated with suicide attempts.

Conclusion

These results suggest that rumination may be a risk factor for suicide attempts and highlight the maladaptive nature of reflection in patients with major depressive episodes.

Peer Review reports

Introduction

Suicide is a tremendous challenge for global public health, with close to 800,000 lives lost to suicide every year [1]. Between half and two-thirds of all completed suicides are committed by people suffering from mood disorders [2]. Patients with major affective disorders, especially those diagnosed with major depressive disorder (MDD) and bipolar disorder (BD), are at very high risk of death by suicide, with a lifetime prevalence of attempted suicide of around 31 and 33.9%, respectively [3]. As a proposed lethality measure, the ratio of suicide attempts is also comparable in MDD and BD, at 10.2 and 11.1, respectively [4]. Accordingly, identification of the risk factors for suicide attempts in major affective disorders may improve suicidal risk recognition and contribute to targeted interventions. Several clinical and psychological indicators, such as depression, hopelessness, and impulsivity, are good predictors of suicidal ideation [4, 5]. However, the critical vulnerabilities that predict the risk of suicide attempts have not yet been fully elucidated.

In recent years, rumination has been suggested as a potential cognitive factor related to suicide. According to Nolen-Hoeksema’s Response Styles Theory [6], rumination is described as a stable trait response pattern in which individuals passively and repetitively focus on the reasons, consequences, and symptoms of their distress rather than engage in proactive problem-solving. Rumination is related to malicious excessive self-referential processes and is generally regarded as a maladaptive cognitive style due to its repetitive and passive thinking properties. It can exacerbate psychopathology and interfere with dynamic approach behavior [7]. Rumination has been linked with prolonged negative mood and aggravated depressive symptoms in non-clinical individuals [8, 9], along with the course of the disease and episode number in both MDD and BD patients [10, 11].

Treynor and colleagues [12] described two principal components of rumination: brooding and reflection. Brooding is characterized by dwelling on the outcomes of negative emotions, while reflection pertains to pondering the reasons for a depressed mood. It has been suggested that brooding may be a maladaptive process, while reflection may be an adaptive strategy because it may facilitate problem-solving in the long run; therefore, studies should assess global rumination and both aspects of rumination separately. Rumination has been shown to be a good predictor of the presence and duration of suicidal ideation [13,14,15]. In contrast, there is limited and inconclusive evidence regarding the association between rumination (both global rumination and its two subsets) and suicide attempts, especially in relation to depressive episodes [16].

In a non-clinical cross-sectional survey of 1696 college students, brooding was significantly related to suicide risk and attempts [17]. Valderrama et al. [18] found an indirect relationship between brooding and suicidal behavior, independent of reflection; however, Surrence and colleagues failed to observe differences in brooding and reflection between suicide attempters and non-attempters in a study of 96 college undergraduates. In contrast, reflection appears to be positively associated with suicidal thoughts in individuals with a history of suicide attempts [19]. Krajniak et al. [20] followed up 143 college students for 2–3 years, 32 of whom had a history of suicide attempts. Those who attempted suicide showed higher levels of suicidal ideation at follow-up, and this association was mediated by global rumination.

When it comes to clinical studies, global rumination was found to be a core symptom of “suicidal syndrome” in a study of 2383 schizophrenia patients and 1920 mood disorder patients; however, these findings were not specific to major mood disorders [21]. Psychiatric inpatients reporting a history of suicide attempts had higher brooding levels than non-suicidal individuals, even after controlling for patients’ depressive symptoms [22]. A longitudinal study of 286 individuals seeking psychiatric emergency services found no significant cross-sectional or prospective correlations between global rumination and suicide attempts. In contrast, brooding, rather than reflection, was related to a lifetime history of suicide attempts; however, brooding could not predict future suicide attempts [23]. Similarly, in a cross-sectional study of 83 suicide attempters admitted to an Accident and Emergency department, Cameron et al. [24] found ruminative brooding was directly correlated with both suicide attempts and ideation accompanied by current low mood.

The literature reviewed above suggests that suicide attempts may be related to global rumination and brooding, rather than reflection. This assertion is supported by a recent meta-analysis showing moderate associations between suicide attempts and both global rumination and brooding (Hedge’s g = 0.26 and 0.47, respectively), but no association between suicide attempts and reflection (Hedge’s g = 0.09) [16]. Nonetheless, these findings should be interpreted with caution and require further refinement as few evaluated clinical samples. Furthermore, there is remarkable heterogeneity among the samples from the limited available clinical studies, which may affect the findings’ reliability and limit their generalizability. In the published clinical studies to date, most participant samples comprised patients with mood disorders, together with patients with schizophrenia, schizoaffective disorder, substance abuse, or other confounding factors [21, 22, 25]. There is currently no available data specific to major depressive episodes.

This study aimed to investigate whether rumination is a risk factor for suicide attempts in major affective disorder. Rumination is prevalent in both depression and bipolar disorder, meaning the patients’ negative self-concept/schemas might be similar during the depressive episodes which are characteristic of each disorder [11, 26, 27]. To improve sample homogeneity, we only included patients with major depressive episodes to eliminate the influence of other mental diseases or mixed symptoms. We put forward two hypotheses: 1) suicide attempters would display a higher degree of rumination, including global rumination and both subcategories of rumination, than non-attempters; and 2) global rumination and brooding would be the prominent risk factors for suicide attempts among patients suffering from major depressive episodes.

Methods

Study design

This study adopted a retrospective design. Data, including demographic data, clinical assessments, and rumination assessments, were collected from patients diagnosed with major affective disorders.

Participants

The sample patients were recruited from those hospitalized at the Affiliated Brain Hospital of Nanjing Medical University between June 2019 and May 2020. Patients were enrolled who met the diagnostic criteria of the Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV-TR) [28] for major depressive disorder or bipolar disorder with current major depressive episode. The inclusion criteria were: (1) confirmed diagnosis according to the Chinese version of the Mini-International Neuropsychiatric Interview (MINI) [29]; (2) Han Chinese ethnicity aged 16–65 years with a junior high school education or above; (3) 17-item Hamilton Rating Scale for Depression (HRSD-17) score [30] > 7; (4) Young Mania Rating Scale (YMRS) [31] score < 5; (5) Brief Psychiatric Rating Scale (BPRS) score [32]<35; and (6) no structured psychotherapy within 6 months. The exclusion criteria included current mania/hypomania episode and mixed state of bipolar disorder, comorbidity with other mental disorders, psychotic symptoms, severe and unstable physical disease, and pregnancy or lactation.

Three hundred sixty-nine consecutively admitted patients were screened in the initial study. Fifty-five patients were excluded as they did not meet the inclusion criteria, including 10 with mixed episodes, seven with a comorbid personality disorder, 12 with psychotic symptoms, 12 with a comorbid anxiety disorder, three with comorbid obsessive-compulsive disorder, five with comorbid alcohol dependence, and six with only primary school education. In total, 314 participants were enrolled in the study, of which four were excluded as too much data were missing from their self-assessment scales. Thus, a total of 309 subjects were included in the statistical analyses. The local ethics committee approved this study, and all subjects gave written informed consent before participating.

Measures

A suicide attempt is defined as self-harm behavior with an inferred or actual intention to die [33]. Each patient’s history of suicide attempts was evaluated as part of the clinical interview upon admission to the hospital. These data were obtained from the patient’s medical records and also covered in the MINI and HRSD assessments. Further, the patient’s responses to the Nurse’s Global Assessment of Suicide Risk (NGASR) [34] confirmed their suicide attempt history. The NGASR is a structured assessment to assess suicide risk; the Chinese version has demonstrated good reliability and validity [35]. The NGASR comprises 15 questions. The 7th item requires the doctor to ask “if there was a history of prior suicide attempt’; this item is scored 0 for “NO” and 3 for “YES.” Based on the above data, participants were divided into two groups: suicide attempters (SA) and non-suicide attempters (NSA).

The Ruminative Responses Scale (RRS) is the most commonly used measure of rumination. It contains a 22-item self-report inventory which is a revision of the Response Styles Questionnaire [36]. The Chinese version of the RRS, which has demonstrated reliability among Chinese college students and patients with major depression [37, 38], was employed in the present study. The RRS is composed of three dimensions: brooding, reflection, and depression-related rumination. Brooding and reflection are considered the main components of rumination, while depression-related rumination overlaps more with depressive symptoms and is often removed [12]. We used the brooding and reflection sub-scores (five items each) and the total score (the sum of the brooding and reflection scales, reflecting global rumination) as the candidate risk factors predicting suicide attempts in the subsequent analyses.

As mentioned above, a series of measurement methods evaluated participants’ clinical symptoms. The HRSD-17, Hamilton Anxiety Rating Scale (HAMA) [39], YMRS, and BPRS were used to assess each patient’s severity of depression, anxiety symptoms, manic symptoms, and psychotic symptoms, respectively. All assessments were completed within 3 days of the patient’s hospitalization.

Statistical analyses

Data management and analyses were performed using SPSS 23.0. Two-sample t-tests, non-parametric tests, or chi-square analyses were utilized to compare the groups with respect to demographic data, clinical data, and the RRS and its subscale scores. Partial correlations (with Bonferroni correction) were performed to explore the relationships between rumination and each major clinical variable. Next, binary logistic regression was used to predict whether ruminative thinking was a risk factor for suicide attempts. To control for the effects of clinical factors as much as possible, demographic and clinical variables with a P<0.1 in the first step of the single factor analysis were selected as covariates for the regression analysis. The total and factor scores of the RRS were analyzed separately and the VIF value evaluated to test for multicollinearity. Further, the Hosmer-Lemeshow test was used to assess the goodness of fit of the logistic regression models.

Results

Demographic and clinical data

The full cohort included 87 suicide attempters and 222 non-attempters; 170 were diagnosed with MDD and 139 with BD. As shown in Table 1, the groups did not differ significantly by education or gender; however, the mean age of suicide attempters was significantly lower than non-attempters (U = 7335.500, P = 0.001). There were no significant differences between the two groups with respect to HRSD, HAMA, YMRS, BPRS, disease duration, episode frequency, family history, and MDD/BD diagnosis. The P values for HRSD (t = − 1.725, P = 0.086) and episode frequency (U = 8467.500, P = 0.082) were less than 0.1, so these variables were included as covariates, along with age, in the subsequent regression analyses. Given the close relationship between anxiety and suicide [40], we also included HAMA as an independent variable. Suicide attempters showed much higher NGASR scores than non-attempters; however, because of the intrinsic relationship between suicide risk and attempts, the NGASR scores were not included in the regression analysis.

Table 1 Characteristics of the study sample

The relationships between rumination and major clinical variables

Cronbach’s α was first calculated to test the reliability of the RRS in the current sample. The internal consistency was found to be adequate for the global rumination score (α = 0.857) and both brooding (α = 0.782) and reflection (α = 0.734) scores. As can be seen from Table 2, the suicide attempters reported significantly higher levels of global rumination, brooding, and reflection compared to the non-attempters.

Table 2 Comparison of rumination between SA and NSA groups

Research suggests that rumination may be affected by age and sex [41, 42]; therefore, a partial correlation analysis controlling for sex and age was used to characterize the correlations between rumination and HRSD, HAMA, course of the disease, and episode frequency. There were positive relationships between global rumination and both HRSD (r = 0.250, P = 0.000) and episode frequency (r = 0.193, P = 0.001). Brooding was positively correlated with HRSD (r = 0.252, P = 0.000), while reflection was significantly related to HRSD (r = 0.207, P = 0.000) and episode frequency (r = 0.183, P = 0.001). The threshold for a significant correlation was set at P < 0.002, Bonferroni corrected (Table 3).

Table 3 Correlations between rumination and major clinical variables

Association between rumination and suicide attempts

As mentioned above, HRSD, HAMA, episode frequency, and age were included as covariates in the binary logistic regression to explore the relationship between rumination and suicide attempts. Consistent with our hypothesis, global rumination was significantly associated with suicide attempts [OR (95% CI) = 1.101 (1.046, 1.159), P = 0.000]. In terms of the rumination subtypes, patients with higher levels of reflection were more likely to report a history of suicide attempts [OR (95%CI) = 1.184 (1.042, 1.345), P = 0.009]. In contrast, brooding was not a statistically significant predictor of suicide attempt history [OR (95% CI) = 1.030 (0.916, 1.158), P = 0.622]. Table 4 presents the logistic regression summary statistics. Based on these findings, a nomogram was configured (Fig. 1).

Table 4 Logistic regressions examining concurrent associations
Fig. 1
figure1

Nomogram to estimate the risk of suicide attempt. Figures A and B show the relationships between suicide attempts and both GR and its subcomponents, respectively. Each risk factor can be vertically correlated to the corresponding “Points.” “Total Points” sums up the “Points” for all risk factors to match the “Risk of the suicide attempt”. GR, Global Rumination

Discussion

This study was designed to determine the relationship between rumination and suicide attempts in a sample of hospital inpatients with major depressive episodes. Consistent with our hypothesis, depressive suicide attempters exhibited significantly higher rumination (including its subtypes, brooding and reflection) than non-attempters. However, it was somewhat surprising that global rumination and reflection, not brooding, were associated with suicide attempts, even when controlling for the severity of depression and anxiety symptoms.

The RRS total score provides an overall measure of global depressive rumination. Consistent with our findings, Fazakas-Dehoog et al. [43] found that suicide attempters had higher RRS scores than non-attempters in a non-clinical sample. Likewise, Yaseen et al. [44] found that psychiatric patients with a history of suicide attempts showed higher levels of ruminative flooding and regard rumination as a vital factor of the “suicide trigger state.” Theoretically, there may be a persuasive pathological association between rumination and suicide attempts. Repetitive negative thinking may result in helplessness and temptation, which could generate suicidal thoughts; then, the transition from considering suicide to attempting suicide could be promoted by repeated exposure to suicidal thoughts and imagery [45]. In one study, at baseline, suicide attempters scored higher on global rumination than non-attempters and exhibited increased vulnerability to suicidality at a two-year follow-up [20]. Our results broaden the evidence that global rumination is linked with suicide attempts in clinical samples [16], with our study broadening those findings to patients with major depressive episodes.

The most striking result of this study is that reflection, rather than brooding, was associated with suicide attempts. Traditionally, it has been argued that reflection is associated with increased depression concurrently and decreased depressive symptoms longitudinally [12], meaning it may have a protective effect to some extent [46]. However, there are other possible interpretations of the role of reflection.

Several studies have found associations between reflection and suicidal ideation [47] or a history of both non-suicidal self-injury and suicide attempts [25], suggesting that reflection may at times be a negative coping strategy. Reflection involves a tendency to understand why one feels distressed; however, if repetitive attempts are fruitless, a person could fall into negative thinking cycles, resulting in impaired mood regulation and problem-solving [48]. From another perspective, reflection might be adaptive only if there are no negative cognitive biases [49]. Furthermore, in another study, reflection was positively associated with suicidal intent in suicide attempters with low problem-solving skills [50]. These studies present potential mechanisms underlying our finding of reflection as a risk factor for suicide attempts in the current sample of participants suffering from a major depressive episode. We speculate that reflection when suffering negative emotions might increase vulnerability to everything from suicidal thoughts to suicide attempts.

Another important finding was, that although the brooding and reflection scores of the suicide attempters were higher than the non-attempters, the regression analysis did not find brooding to be a significant risk factor for attempted suicide. This outcome is contrary to previous findings which have suggested that brooding is cognitively maladaptive and more strongly associated with a history of suicide attempts than reflection in psychiatric inpatients [17, 22]. The reason for this unexpected finding is not apparent but may have something to do with the critical contribution of brooding to clinical symptoms. These results are in accord with Surrence’s study [19] which found that brooding did not predict suicide attempts. These authors argued that the impact of brooding on suicide is primarily through an increase in depressive symptoms and hopelessness. Our research also found that brooding was only related to the severity of depression as measured by various clinical indicators; thus, brooding may contribute more to the depressive symptoms which somehow influence suicide. However, caution must be applied when interpreting these findings which should be replicated in mood disorders to develop a full picture and confidence in the generalizability of the findings.

The present study is one of the first attempts to examine the relationship between rumination and suicide attempts in patients with major affective disorders. These results may offer valuable insight into the vital role of ruminative thinking in attempted suicide in depression. Understanding the link between rumination and suicide will further highlight the importance of rumination assessment in clinical practice, regardless of MDD or BD diagnoses. The results indicate that for depressed patients with high levels of global rumination and reflection, clinicians must pay close attention to the determination of suicide risk during treatment. Specifically, interventions that focus on alleviating rumination, such as Rumination-focused Cognitive Behavioural Therapy [51], might be particularly beneficial for suicide prevention in patients with depression.

Limitations

Several limitations of this research must be noted. Firstly, it is now well established there is high psychiatric comorbidity in both MDD and BD [52, 53]. Stricter inclusion criteria were adopted in this study to eliminate the influence of comorbidity, which resulted in a relatively small sample size. Another source of weakness was the cross-sectional design of this study, which might undermine the determination of causality. A longitudinal investigation is required to determine whether initial levels of rumination are reliable predictors of future suicide attempts in major affective disorder, especially given that some MDD patients may convert to BD and be challenged by manic/hypomanic episodes over time. Thirdly, we concentrated only on the significance of rumination and did not measure the associations between suicide attempts and other risk factors, such as hopelessness and impulsivity [5]. Additionally, structural and functional changes in specific brain regions may be involved in both rumination and suicide [54]. The predictive efficacy of rumination for suicide attempts may be significantly improved when combined with comprehensive clinical assessment and neuroimaging techniques, such as rumination-related neurophysiological or functional imaging.

Conclusion

Overall, the current study demonstrates a critical role of global rumination and reflection in suicide attempts. Notwithstanding the relatively limited sample size, this work offers valuable insight into the relationship between rumination and suicide attempts in major depressive episodes. Suicide attempters exhibited higher rumination scores (both global scores and scores for each subtype); however, only global rumination and reflection were substantially correlated with suicide attempts after controlling for depression and anxiety levels. The current data add to the growing body of evidence indicating that rumination confers a risk for suicide attempts and expands our understanding of maladaptive attributes of reflection in major affective disorders. Future studies using a broader range of rumination assessments could shed more light on the role of rumination in predicting suicidal behavior in clinical practice.

Availability of data and materials

The datasets generated during the current study are not publicly available due to the subjects’ privacy but are available from the corresponding author on reasonable request.

Abbreviations

BD:

Bipolar Disorder

BPRS:

Brief Psychiatric Rating Scale

DSM-IV-TR:

Statistical Manual of Mental Disorders, 4th Edition, Text Revision

HAMA:

Hamilton Anxiety Rating Scale

MDD:

Major Depressive Disorder

MINI:

Mini-International Neuropsychiatric Interview

NGASR:

Nurse’s Global Assessment of Suicide Risk

NSA:

Non-suicide attempters

RRS:

Ruminative Responses Scale

SA:

Suicide attempters

YMRS:

Young Mania Rating Scale

References

  1. 1.

    World Health Organization. Suicide. https://www.who.int/news-room/fact-sheets/detail/suicide. Accessed 2 Sept 2019.

  2. 2.

    Isometsä E. Suicidal behaviour in mood disorders—who, when, and why? Can J Psychiatr. 2014;59:120–30.

    Article  Google Scholar 

  3. 3.

    Miller JN, Black DW. Bipolar disorder and suicide: a review. Curr Psychiatry Rep. 2020;22:6.

    PubMed  Article  PubMed Central  Google Scholar 

  4. 4.

    Baldessarini RJ, Tondo L, Pinna M, Nuñez N, Vázquez GH. Suicidal risk factors in major affective disorders. Br J Psychiatry J Ment Sci. 2019;215:621–6.

    Article  Google Scholar 

  5. 5.

    Klonsky ED, May AM, Saffer BY. Suicide, suicide attempts, and suicidal ideation. Annu Rev Clin Psychol. 2016;12:307–30.

    PubMed  Article  PubMed Central  Google Scholar 

  6. 6.

    Nolen-Hoeksema S, Wisco BE, Lyubomirsky S. Rethinking rumination. Perspect Psychol Sci J Assoc Psychol Sci. 2008;3:400–24.

    Article  Google Scholar 

  7. 7.

    Watkins ER, Roberts H. Reflecting on rumination: consequences, causes, mechanisms and treatment of rumination. Behav Res Ther. 2020;127:103573.

    PubMed  Article  PubMed Central  Google Scholar 

  8. 8.

    Nolen-Hoeksema S, Morrow J, Fredrickson BL. Response styles and the duration of episodes of depressed mood. J Abnorm Psychol. 1993;102:20–8.

    CAS  PubMed  Article  PubMed Central  Google Scholar 

  9. 9.

    Lyubomirsky S, Layous K, Chancellor J, Nelson SK. Thinking about rumination: the scholarly contributions and intellectual legacy of Susan Nolen-Hoeksema. Annu Rev Clin Psychol. 2015;11:1–22.

    PubMed  Article  PubMed Central  Google Scholar 

  10. 10.

    Nolen-Hoeksema S. The role of rumination in depressive disorders and mixed anxiety/depressive symptoms. J Abnorm Psychol. 2000;109:504–11.

    CAS  Article  Google Scholar 

  11. 11.

    de M Silveira É, Kauer-Sant’Anna M. Rumination in bipolar disorder: a systematic review. Braz J Psychiatry. 2015;37:256–63.

    Article  Google Scholar 

  12. 12.

    Treynor W, Gonzalez R, Nolen-Hoeksema S. Rumination reconsidered: a psychometric analysis. Cogn Ther Res. 2003;27:247–59.

    Article  Google Scholar 

  13. 13.

    Burke TA, Connolly SL, Hamilton JL, Stange JP, Abramson LY, Alloy LB. Cognitive risk and protective factors for suicidal ideation: a two year longitudinal study in adolescence. J Abnorm Child Psychol. 2016;44:1145–60.

    PubMed  PubMed Central  Article  Google Scholar 

  14. 14.

    Smith JM, Alloy LB, Abramson LY. Cognitive vulnerability to depression, rumination, hopelessness, and suicidal ideation: multiple pathways to self-injurious thinking. Suicide Life Threat Behav. 2006;36:443–54.

    PubMed  Article  PubMed Central  Google Scholar 

  15. 15.

    Teismann T, Forkmann T. Rumination, entrapment and suicide ideation: a mediational model: rumination, entrapment and suicide ideation: a mediational model. Clin Psychol Psychother. 2017;24:226–34.

    PubMed  Article  PubMed Central  Google Scholar 

  16. 16.

    Rogers ML, Joiner TE. Rumination, suicidal ideation, and suicide attempts: a meta-analytic review. Rev Gen Psychol. 2017;21:132–42.

    Article  Google Scholar 

  17. 17.

    Holdaway AS, Luebbe AM, Becker SP. Rumination in relation to suicide risk, ideation, and attempts: exacerbation by poor sleep quality? J Affect Disord. 2018;236:6–13.

    PubMed  PubMed Central  Article  Google Scholar 

  18. 18.

    Valderrama J, Miranda R, Jeglic E. Ruminative subtypes and impulsivity in risk for suicidal behavior. Psychiatry Res. 2016;236:15–21.

    PubMed  PubMed Central  Article  Google Scholar 

  19. 19.

    Surrence K, Miranda R, Marroquín BM, Chan S. Brooding and reflective rumination among suicide attempters: cognitive vulnerability to suicidal ideation. Behav Res Ther. 2009;47:803–8.

    PubMed  Article  PubMed Central  Google Scholar 

  20. 20.

    Krajniak M, Miranda R, Wheeler A. Rumination and pessimistic certainty as mediators of the relation between lifetime suicide attempt history and future suicidal ideation. Arch Suicide Res. 2013;17:196–211.

    PubMed  Article  PubMed Central  Google Scholar 

  21. 21.

    Ahrens B, Linden M. Is there a suicidality syndrome independent of specific major psychiatric disorder? Results of a split half multiple regression analysis. Acta Psychiatr Scand. 1996;94:79–86.

    CAS  PubMed  Article  PubMed Central  Google Scholar 

  22. 22.

    Grassia M, Gibb BE. Rumination and lifetime history of suicide attempts. Int J Cogn Ther. 2009;2:400–6.

    PubMed  PubMed Central  Article  Google Scholar 

  23. 23.

    Horwitz AG, Czyz EK, Berona J, King CA. Rumination, brooding, and reflection: prospective associations with suicide ideation and suicide attempts. Suicide Life Threat Behav. 2018;49:1085–93.

    PubMed  PubMed Central  Article  Google Scholar 

  24. 24.

    Cameron S, Brown VJ, Dritschel B, Power K, Cook M. Understanding the relationship between suicidality, current depressed mood, personality, and cognitive factors. Psychol Psychother. 2017;90:530–49.

    PubMed  Article  PubMed Central  Google Scholar 

  25. 25.

    Polanco-Roman L, Jurska J, Quiñones V, Miranda R. Brooding, reflection, and distraction: relation to non-suicidal self-injury versus suicide attempts. Arch Suicide Res Off J Int Acad Suicide Res. 2015;19:350–65.

    Article  Google Scholar 

  26. 26.

    Cludius B, Mennin D, Ehring T. Emotion regulation as a transdiagnostic process. Emotion. 2020;20:37–42.

    PubMed  Article  PubMed Central  Google Scholar 

  27. 27.

    Ghaznavi S, Deckersbach T. Rumination in bipolar disorder: evidence for an unquiet mind. Biol Mood Anxiety Disord. 2012;2:2.

    PubMed  PubMed Central  Article  Google Scholar 

  28. 28.

    American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV-TR). Washington: American Psychiatric Association; 2000.

    Book  Google Scholar 

  29. 29.

    Si T-M, Shu L, Dang W-M, Se Y-A, Chen J-X, Dong W-T, et al. Evaluation of the reliability and validity of Chinese version of the Mini-international neuropsychiatric interview in patients with mental disorders. Chin Ment Health J. 2009;23:493–503.

    CAS  Google Scholar 

  30. 30.

    Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960;23:56–62.

    CAS  PubMed  PubMed Central  Article  Google Scholar 

  31. 31.

    Young RC, Biggs JT, Ziegler VE, Meyer DA. A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry J Ment Sci. 1978;133:429–35.

    CAS  Article  Google Scholar 

  32. 32.

    Overall JE, Gorham DR. The brief psychiatric rating scale. Psychol Rep. 1962;10:799–812.

    Article  Google Scholar 

  33. 33.

    Turecki G, Brent DA, Gunnell D, O’Connor RC, Oquendo MA, Pirkis J, et al. Suicide and suicide risk. Nat Rev Dis Primer. 2019;5:74.

    Article  Google Scholar 

  34. 34.

    Cutcliffe JR, Barker P. The nurses’ global assessment of suicide risk (NGASR): developing a tool for clinical practice. J Psychiatr Ment Health Nurs. 2004;11:393–400.

    CAS  PubMed  Article  PubMed Central  Google Scholar 

  35. 35.

    Guo J, Lu Q, Chen X, Liu F. Reliability and validity of the retranslated China version of nurses’ global assessment of suicide risk scale. Chin J Pract Nurs. 2018;34:1841–5.

    Google Scholar 

  36. 36.

    Nolen-Hoeksema S, Morrow J. A prospective study of depression and posttraumatic stress symptoms after a natural disaster: the 1989 Loma Prieta earthquake. J Pers Soc Psychol. 1991;61:115–21.

    CAS  Article  Google Scholar 

  37. 37.

    Han X, Yang H. Chinese version of Nolen-Hoeksema ruminative responses scale (RRS) used in 912 college students: reliability and validity. Chinese J Clin Psychol. 2009;17:550–1.

    Google Scholar 

  38. 38.

    Wang Q, Zhu X, Yi J. Reliability and validity of the Chinese version of rumination response scale in depressed patients. Nerv Dis Ment Health. 2011;11:544–6.

    Google Scholar 

  39. 39.

    Hamilton M. The assessment of anxiety states by rating. Br J Med Psychol. 1959;32:50–5.

    CAS  PubMed  Article  PubMed Central  Google Scholar 

  40. 40.

    Orri M, Galera C, Turecki G, Forte A, Renaud J, Boivin M, et al. Association of childhood irritability and depressive/anxious mood profiles with adolescent suicidal ideation and attempts. JAMA Psychiatry. 2018;75:465–73.

    PubMed  PubMed Central  Article  Google Scholar 

  41. 41.

    Emery L, Sorrell A, Miles C. Age differences in negative, but not positive, rumination. J Gerontol B Psychol Sci Soc Sci. 2020;75:80–4.

    PubMed  Article  PubMed Central  Google Scholar 

  42. 42.

    Shors TJ, Millon EM, Chang HYM, Olson RL, Alderman BL. Do sex differences in rumination explain sex differences in depression? J Neurosci Res. 2017;95:711–8.

    CAS  PubMed  Article  PubMed Central  Google Scholar 

  43. 43.

    Fazakas-Dehoog LL. An integrative models of suicidal behaviour. Dissertation Abstracts International: Section B: The Sciences and Engineering. 2008;69:3264.

    Google Scholar 

  44. 44.

    Yaseen ZS, Gilmer E, Modi J, Cohen LJ, Galynker II. Emergency room validation of the revised suicide trigger scale (STS-3): a measure of a hypothesized suicide trigger state. PLoS One. 2012;7:e45157.

    CAS  PubMed  PubMed Central  Article  Google Scholar 

  45. 45.

    Law KC, Tucker RP. Repetitive negative thinking and suicide: a burgeoning literature with need for further exploration. Curr Opin Psychol. 2018;22:68–72.

    PubMed  Article  PubMed Central  Google Scholar 

  46. 46.

    Crane C, Barnhofer T, Williams JMG. Reflection, brooding, and suicidality: a preliminary study of different types of rumination in individuals with a history of major depression. Br J Clin Psychol. 2007;46:497–504.

    PubMed  Article  PubMed Central  Google Scholar 

  47. 47.

    Cheref S, Lane R, Polanco-Roman L, Gadol E, Miranda R. Suicidal ideation among racial/ethnic minorities: moderating effects of rumination and depressive symptoms. Cultur Divers Ethnic Minor Psychol. 2015;21:31–40.

    PubMed  Article  PubMed Central  Google Scholar 

  48. 48.

    Miranda R, Nolen-Hoeksema S. Brooding and reflection: rumination predicts suicidal ideation at one-year follow up in a community sample. Behav Res Ther. 2007;45:3088–95.

    PubMed  PubMed Central  Article  Google Scholar 

  49. 49.

    Joormann J, Dkane M, Gotlib IH. Adaptive and maladaptive components of rumination? Diagnostic specificity and relation to depressive biases. Behav Ther. 2006;37:269–80.

    PubMed  Article  PubMed Central  Google Scholar 

  50. 50.

    Sharaf AY, Lachine OA, Thompson EA. Rumination, social problem solving and suicide intent among egyptians with a recent suicide attempt. Arch Psychiatr Nurs. 2018;32:86–92.

    PubMed  Article  PubMed Central  Google Scholar 

  51. 51.

    Cook L, Mostazir M, Watkins E. Reducing stress and preventing depression (RESPOND): randomized controlled trial of web-based rumination-focused Cognitive Behavioral Therapy for high-ruminating university Students. J Med Internet Res. 2019;21:e11349.

    PubMed  PubMed Central  Article  Google Scholar 

  52. 52.

    Grande I, Berk M, Birmaher B, Vieta E. Bipolar disorder. Lancet. 2016;387:1561–72.

    Article  Google Scholar 

  53. 53.

    Hasin DS, Sarvet AL, Meyers JL, Saha TD, Ruan WJ, Stohl M, et al. Epidemiology of adult DSM-5 major depressive disorder and its specifiers in the United States. JAMA Psychiatry. 2018;75:336–46.

    PubMed  PubMed Central  Article  Google Scholar 

  54. 54.

    Schmaal L, van Harmelen A-L, Chatzi V, Lippard ETC, Toenders YJ, Averill LA, et al. Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies. Mol Psychiatry. 2020;25:408–27.

    PubMed  Article  PubMed Central  Google Scholar 

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Acknowledgments

We want to express special gratitude to the participants and their families for their cooperation and patience across this study. We also thank the nursing staff of the Mood Disorders Department of the Affiliated Brain Hospital of Nanjing Medical University for their help in data collection.

Funding

This work was supported by the National Key R&D Program of China (2018YFC1314601); National Natural Science Foundation of China (81871066); Jiangsu Provincial Key Research and Development Program (BE2018609, BE2019675); Jiangsu Provincial Medical Innovation Team of the Project of Invigorating Health Care through Science, Technology and Education (CXTDC2016004); Key Project supported by the Medical Science and Technology Development Foundation, Jiangsu Commission of Health (K2019011); Jiangsu Provincial Medical Youth Talent (QNRC2016049); the Science and Technology Program of Nanjing (201803030).

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Authors

Contributions

Conception and design of the study: Hao Tang, Zhijian Yao, Qing Lu. Acquisition and formal analysis of data: Tingting Xiong, Jiabo Shi, Yu Chen, Xiaoxue Liu. Making tables and graphing figures: Hao Tang, Siqi Zhang, Huan Wang. Writing-original draft: Hao Tang. Writing-review & editing: Zhijian Yao, Qing Lu. All authors read and approved the final manuscript.

Corresponding authors

Correspondence to Qing Lu or Zhijian Yao.

Ethics declarations

Ethics approval and consent to participate

This study was approved by the Medical Ethics Committee of the Affiliated Brain Hospital of Nanjing Medical University (No.2018-KY065–01). All the research procedures involving human participants followed the Declaration of Helsinki in 1964 and its subsequent amendments. Written informed consent was obtained from all participants and a parent or legal guardian (if the participant is younger than 18 years).

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Not applicable.

Competing interests

The authors declare that they have no competing interests.

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Tang, H., Xiong, T., Shi, J. et al. Global and reflective rumination are related to suicide attempts among patients experiencing major depressive episodes. BMC Psychiatry 21, 117 (2021). https://0-doi-org.brum.beds.ac.uk/10.1186/s12888-021-03119-z

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Keywords

  • Major depressive disorder
  • Bipolar disorder
  • Rumination
  • Suicide attempt
  • Risk factor