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Table 2 Significant differences in relative regional gray matter volumes between ADHD participants with good and poor methylphenidate response

From: Regional brain volume predicts response to methylphenidate treatment in individuals with ADHD

Cluster

Region

BA

Hemisphere

MNI coordinates

T value

Cluster-level p valuea

Cluster size (voxels)b,e

x

y

z

A

Good responders > Poor responders

 Left Putamen cluster c

  Putamen_L

 

–

L

−30

−10

−3

3.84

0.0319

515

B

Good responders < Poor responders

 Bilateral Precuneus cluster d

         

 Precuneus

 

31

L

−6

−54

36

4.10

0.0115

1079

  1. Abbreviations: ADHD Attention Deficit Hyperactivity Disorder, BA Brodmann area, L Left, R Right, MNI Montreal Neurological Institute
  2. aRegions were identified based on the Harvard-Oxford Atlas
  3. bStatistical threshold was all set at FWE-corrected cluster-level p < 0.05 (controlled for non-stationarity), with cluster-forming voxel-level p < 0.01
  4. cA small volume correction within the striatal mask
  5. dA small volume correction within the DMN mask
  6. eIsotropic voxel size = 1.5 × 1.5 × 1.5 mm3