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Table 3 Regression analysis of the association between drug addiction features and candidate SNPs of OPRM1 gene

From: Genetic susceptibility of opioid receptor genes polymorphism to drug addiction: A candidate-gene association study

SNP ID

Covariate

Regression coefficients B B vs Expected. B*

P-value**

rs648893

Age

0.42

1.53

< 0.0001

Smoking

−1.27

0.28

< 0.0001

Work

0.10

1.10

0.55

Marital status

−1.34

0.26

< 0.0001

GG

−0.28

0.75

0.33

AG

0.11

1.11

0.44

AA

reference

rs609148

Age

0.42

1.52

< 0.0001

Smoking

−1.27

0.28

< 0.0001

Work

0.08

1.09

0.61

Marital status

−1.33

0.26

< 0.0001

GG

0.30

1.35

0.27

AG

0.29

1.33

0.31

AA

reference

rs3823010

Age

0.42

1.52

< 0.0001

Smoking

−1.28

0.27

< 0.0001

Work

0.10

1.11

0.53

Marital status

−1.34

0.26

< 0.0001

GG

0.07

1.07

0.92

AG

0.06

1.06

0.93

AA

reference

rs1799971

Age

0.42

1.52

< 0.0001

Smoking

−1.28

0.27

< 0.0001

Work

0.11

1.12

0.50

Marital status

−1.34

0.26

< 0.0001

GG

0.73

2.08

0.23

AG

0.47

1.61

0.01

AA

reference

rs524731

Age

0.42

1.53

< 0.0001

Smoking

−1.30

0.27

< 0.0001

Work

0.06

1.07

0.62

Marital status

−1.35

0.25

< 0.0001

CC

−0.04

0.95

0.90

CA

−0.06

0.93

0.87

AA

reference

rs511435

Age

0.42

1.52

< 0.0001

Smoking

−1.30

0.27

< 0.0001

Work

0.08

1.08

0.69

Marital status

− 1.33

0.26

< 0.0001

CC

0.18

1.20

0.63

CT

0.15

1.16

0.70

TT

reference

rs1381376

Age

0.41

1.51

< 0.0001

Smoking

−1.27

0.28

< 0.0001

Work

0.11

1.11

0.53

Marital status

−1.32

0.26

< 0.0001

CC

0.33

1.39

0.65

CT

0.16

1.18

0.82

TT

reference

rs3778156

Age

0.44

1.55

< 0.0001

Smoking

−1.26

0.28

< 0.0001

Work

0.10

1.10

0.56

Marital status

−1.37

0.25

< 0.0001

GG

0.03

1.03

0.96

AG

−0.19

0.82

0.31

AA

reference

rs2075572

Age

0.42

1.524

< 0.0001

Smoking

−1.26

0.283

< 0.0001

Work

0.10

1.112

0.53

Marital status

−1.34

0.262

< 0.0001

CC

−0.18

0.833

0.34

CG

−0.11

0.896

0.50

GG

reference

0063rs548646

Age

0.43

1.54

< 0.0001

Smoking

−1.29

0.27

< 0.0001

Work

0.10

1.11

0.54

Marital status

−1.31

0.26

< 0.0001

CC

0.05

1.05

0.81

CT

0.01

1.01

0.96

TT

reference

rs671531

Age

0.42

1.52

< 0.0001

Smoking

−1.25

0.28

< 0.0001

Work

0.09

1.09

0.58

Marital status

−1.34

0.26

< 0.0001

GG

0.15

1.16

0.49

AG

0.14

1.15

0.52

AA

reference

  1. * Beta coefficients
  2. ** P-Value < 0.05 is considered as significant