Table 2 Association of the investigated candidate gene polymorphisms with drug addiction
Gene | SNP ID | Allelic and Genotypic Frequencies in Cases and Controls | ||||
|---|---|---|---|---|---|---|
Allele/Genotype | Cases (n = 498) | Controls (n = 496) | P-value* | Chi-square | ||
OPRM1 | rs648893 | A | 734 (0.74) | 723 (0.73) | 0.57 | 0.31 |
G | 256 (0.26) | 267 (0.27) | ||||
AA | 267 (0.54) | 267 (0.54) | 0.34 | 2.1 | ||
AG | 200 (0.4) | 189 (0.38) | ||||
GG | 28 (0.06) | 39 (0.08) | ||||
rs609148 | G | 729 (0.74) | 709 (0.72) | 0.24 | 1.3 | |
A | 255 (0.26) | 279 (0.28) | ||||
GG | 267 (0.54) | 255 (0.52) | 0.42 | 1.7 | ||
GA | 195 (0.4) | 199 (0.4) | ||||
AA | 30 (0.06) | 40 (0.08) | ||||
rs3823010 | G | 905 (0.92) | 901 (0.91) | 0.44 | 0.58 | |
A | 79 (0.08) | 89 (0.09) | ||||
GG | 416 (0.85) | 411 (0.83) | 0.68 | 0.75 | ||
GA | 73 (0.15) | 79 (0.16) | ||||
AA | 3 (0.01) | 5 (0.01) | ||||
rs1799971 | A | 848 (0.86) | 894 (0.9) | 0.002 | 9.4 | |
G | 140 (0.14) | 96 (0.1) | ||||
AA | 364 (0.74) | 404 (0.82) | 0.01 | 9.3 | ||
GA | 120 (0.24) | 86 (0.17) | ||||
GG | 10 (0.02) | 5 (0.01) | ||||
rs511435 | C | 833 (0.84) | 811 (0.82) | 0.18 | 1.7 | |
T | 155 (0.16) | 177 (0.18) | ||||
CC | 353 (0.71) | 336 (0.68) | 0.42 | 1.7 | ||
CT | 127 (0.26) | 139 (0.28) | ||||
TT | 14 (0.03) | 19 (0.04) | ||||
rs524731 | C | 835 (0.85) | 824 (0.83) | 0.43 | 0.60 | |
A | 151 (0.15) | 164 (0.17) | ||||
CC | 356 (0.72) | 345 (0.7) | 0.71 | 0.67 | ||
CA | 123 (0.25) | 134 (0.27) | ||||
AA | 14 (0.03) | 15 (0.03) | ||||
rs1381376 | C | 907 (0.92) | 893 (0.9) | 0.12 | 2.4 | |
T | 77 (0.08) | 97 (0.1) | ||||
CC | 418 (0.85) | 405 (0.82) | 0.25 | 2.7 | ||
CT | 71 (0.14) | 83 (0.17) | ||||
TT | 3 (0.01) | 7 (0.01) | ||||
rs3778156 | A | 909 (0.92) | 899 (0.91) | 0.34 | 0.9 | |
G | 79 (0.08) | 91 (0.09) | ||||
AA | 419 (0.85) | 409 (0.83) | 0.64 | 0.88 | ||
AG | 71 (0.14) | 81 (0.16) | ||||
GG | 4 (0.01) | 5 (0.01) | ||||
rs2075572 | C | 550 (0.56) | 518 (0.52) | 0.11 | 2.5 | |
G | 434 (0.44) | 472 (0.48) | ||||
CC | 160 (0.33) | 142 (0.29) | 0.30 | 2.4 | ||
CG | 230 (0.47) | 234 (0.47) | ||||
GG | 102 (0.21) | 119 (0.24) | ||||
rs548646 | C | 648 (0.68) | 640 (0.66) | 0.33 | 0.93 | |
T | 310 (0.32) | 336 (0.34) | ||||
CC | 223 (0.47) | 215 (0.44) | 0.63 | 0.91 | ||
CT | 202 (0.42) | 210 (0.43) | ||||
TT | 54 (0.11) | 63 (0.13) | ||||
rs671531 | G | 669 (0.68) | 653 (0.66) | 0.33 | 0.92 | |
A | 313 (0.32) | 335 (0.34) | ||||
GG | 230 (0.47) | 223 (0.45) | 0.51 | 1.35 | ||
GA | 209 (0.43) | 207 (0.42) | ||||
AA | 52 (0.11) | 64 (0.13) | ||||
OPRK1 | rs12675595 | G | 897 (0.9) | 894 (0.9) | 0.93 | 0.01 |
A | 95 (0.1) | 96 (0.1) | ||||
GG | 406 (0.82) | 405 (0.82) | 0.95 | 0.1 | ||
GA | 85 (0.17) | 84 (0.17) | ||||
AA | 5 (0.01) | 6 (0.01) | ||||
rs1051660 | C | 882 (0.897) | 869 (0.88) | 0.36 | 0.83 | |
A | 108 (0.11) | 121 (0.12) | ||||
CC | 383 (0.77) | 394 (0.8) | 0.66 | 0.81 | ||
CA | 103 (0.21) | 94 (0.19) | ||||
AA | 9 (0.02) | 7 (0.01) | ||||
rs6985606 | C | 217 (0.67) | 664 (0.67) | NA | NA | |
T | 327 (0.33) | 324 (0.33) | ||||
CC | 217 (0.44) | 223 (0.45) | 0.96 | 0.07 | ||
CT | 219 (0.45) | 218 (0.44) | ||||
TT | 54 (0.11) | 53 (0.11) | ||||
rs997917 | T | 529 (0.54) | 552 (0.56) | 0.30 | 1.08 | |
C | 455 (0.46) | 432 (0.44) | ||||
TT | 139 (0.28) | 163 (0.33) | 0.20 | 3.2 | ||
TC | 251 (0.51) | 226 (0.46) | ||||
CC | 102 (0.21) | 103 (0.21) | ||||
rs702764 | T | 788 (0.8) | 790 (0.8) | 0.91 | 0.01 | |
C | 202 (0.2) | 200 (0.2) | ||||
TT | 314 (0.63) | 320 (0.65) | 0.69 | 0.72 | ||
TC | 160 (0.32) | 150 (0.3) | ||||
CC | 21 (0.04) | 25 (0.05) | ||||
rs963549 | C | 789 (0.8) | 783 (0.8) | 0.73 | 0.11 | |
T | 195 (0.2) | 201 (0.2) | ||||
CC | 316 (0.64) | 316 (0.64) | 0.62 | 0.93 | ||
CT | 157 (0.32) | 151 (0.31) | ||||
TT | 19 (0.04) | 25 (0.05) | ||||
OPRD1 | rs569356 | A | 910 (0.92) | 912 (0.93) | 0.73 | 0.11 |
G | 74 (0.08) | 70 (0.07) | ||||
AA | 421 (0.86) | 423 (0.86) | 0.89 | 0.23 | ||
AG | 68 (0.14) | 66 (0.13) | ||||
GG | 3 (0.01) | 2 (0.01) | ||||
rs1042114 | T | 912 (0.92) | 912 (0.92) | NA | NA | |
G | 76 (0.08) | 76 (0.08) | ||||
TT | 421 (0.85) | 423 (0.86) | 0.73 | 0.62 | ||
TG | 70 (0.14) | 66 (0.13) | ||||
GG | 3 (0.01) | 5 (0.01) | ||||
rs678849 | C | 527 (0.54) | 545 (0.55) | 0.47 | 0.51 | |
T | 455 (0.46) | 441 (0.45) | ||||
CC | 136 (0.28) | 149 (0.3) | 0.68 | 0.76 | ||
CT | 255 (0.52) | 247 (0.5) | ||||
TT | 100 (0.2) | 97 (0.2) | ||||
rs2236857 | T | 644 (0.65) | 610 (0.62) | 0.10 | 2.7 | |
C | 342 (0.35) | 378 (0.38) | ||||
TT | 218 (0.44) | 188 (0.38) | 0.14 | 3.9 | ||
TC | 208 (0.42) | 234 (0.47) | ||||
CC | 67 (0.14) | 72 (0.15) | ||||
rs2236855 | C | 649 (0.66) | 612 (0.62) | 0.06 | 3.6 | |
A | 333 (0.34) | 376 (0.38) | ||||
CC | 222 (0.45) | 189 (0.38) | 0.08 | 4.9 | ||
CA | 205 (0.42) | 234 (0.47) | ||||
AA | 64 (0.13) | 71 (0.14) | ||||
rs2298896 | T | 573 (0.59) | 539 (0.55) | 0.05 | 3.6 | |
G | 401 (0.41) | 449 (0.45) | ||||
TT | 174 (0.36) | 150 (0.3) | 0.16 | 3.6 | ||
TG | 225 (0.46) | 239 (0.48) | ||||
GG | 88 (0.18) | 105 (0.21) | ||||
rs421300 | A | 559 (0.58) | 540 (0.55) | 0.18 | 1.8 | |
G | 407 (0.42) | 444 (0.45) | ||||
AA | 165 (0.34) | 154 (0.31) | 0.40 | 1.8 | ||
AG | 229 (0.47) | 232 (0.47) | ||||
GG | 89 (0.18) | 106 (0.22) | ||||
rs529520 | A | 523 (0.54) | 556 (0.57) | 0.19 | 1.7 | |
C | 447 (0.46) | 422 (0.43) | ||||
AA | 147 (0.3) | 168 (0.34) | 0.39 | 1.8 | ||
AC | 229 (0.47) | 220 (0.45) | ||||
CC | 109 (0.22) | 101 (0.21) | ||||
rs12749204 | A | 762 (0.77) | 745 (0.75) | 0.33 | 0.95 | |
G | 226 (0.23) | 245 (0.25) | ||||
AA | 296 (0.6) | 282 (0.57) | 0.62 | 0.94 | ||
AG | 170 (0.34) | 181 (0.37) | ||||
GG | 28 (0.06) | 32 (0.06) | ||||
rs2234918 | C | 536 (0.54) | 536 (0.54) | 0.96 | 0.002 | |
T | 454 (0.46) | 452 (0.46) | ||||
CC | 146 (0.29) | 147 (0.3) | 0.99 | 0.01 | ||
CT | 244 (0.49) | 242 (0.49) | ||||
TT | 105 (0.21) | 105 (0.21) | ||||