Inclusion criteria | Exclusion criteria |
---|---|
Age ≥ 18 and able to provide written informed consent | Already taking NAC, selenium or vitamin E History of anaphylactic reaction to NAC |
Current PTSD Meets criteria for DSM-5 diagnosis of PTSD according to CAPS-5 monthly version | Known or suspected clinically unstable systemic medical disorder History of epilepsy Current asthma Recent gastrointestinal ulcers |
Treatment resistant PTSD defined as (a) Minimum 1x trial of an antidepressant (SSRI or SNRI) for minimum 6 weeks without adequate response OR (b) completed a course of trauma-focused psychotherapy | Currently pregnant or breastfeeding Planning to conceive a child during the trial or 3 months following |
If currently taking an antidepressant medication • Minimum of 6-weeks if recently initiated • Dose must be stable for minimum 2 weeks | History of psychotic illness |