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Table 2 Differentially expressed proteins between major depressive disorder and bipolar disorder

From: Comparison of serum protein profiles between major depressive disorder and bipolar disorder

Majority protein IDs

Protein names

Gene names

Fold changea

Student’s t-test statistics (t)

p-valueb

Overexpressed in MDD

 P51149;C9J592;C9J8S3

Ras-related protein Rab-7a

RAB7A

2.729

5.975

4.3 * 10−6

 E9PF63;O75116

Rho-associated protein kinase 2

ROCK2

2.321

4.782

8.0 * 10−5

 P01763

Ig heavy chain V-III region WEA

IGHV3–48

1.205

3.668

0.001

 P08571;D6RFL4

Monocyte differentiation antigen CD14;Monocyte differentiation antigen CD14, urinary form;Monocyte differentiation antigen CD14, membrane-bound form

CD14

1.266

2.875

0.009

 P23083

Ig heavy chain V-I region V35

IGHV10R15–1

2.103

2.739

0.011

 A0A075B6Q5

Ig heavy variable 3–64

IGHV3–64

2.252

2.698

0.013

 P01780

Ig heavy chain V-III region JON

IGHV3–7

0.941

2.404

0.025

Overexpressed in BD

 E7ESC6;Q9UIA9

Exportin-7

XPO7

−2.999

−4.520

1.5 * 10−4

 P03950

Angiogenin

ANG

−1.714

−3.636

0.001

 A0A075B6J4

Ig lambda variable 3–25

IGLV3–25

−2.550

−3.326

0.003

 Q96Q89–4;Q96Q89–3;Q96Q89;Q96Q89–2

Kinesin-like protein KIF20B

KIF20B

−1.298

−2.718

0.012

 A0A096LPE2;P35542;A0A087X0E2

Serum amyloid A-4 protein; Serum amyloid A protein

SAA2-SAA4;SAA4

−0.660

−2.640

0.015

 P05160

Coagulation factor XIII B chain

F13B

−1.120

−2.315

0.030

 D6REX5;P49908;D6RIS9

Selenoprotein P

SEPP1;SELENOP

−0.881

−2.088

0.048

  1. Abbreviations: MDD major depressive disorder, BD bipolar disorder
  2. aFold change calculated by the difference of the logarithmic(2) transferred intensity
  3. bBoldface p-values are significant when adjusting for multiple comparison by using the Benjamini-Hochberg FDR adjusted p-value