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Table 3 Performance of AUDIT-C and biochemical markers for detecting risky drinking

From: Identifying alcohol problems among suicide attempters visiting the emergency department

 

Risky drinking*****

Men (N = 65)

Women (N = 49)

AUC

(95% CI)

SEN

(95% CI)

SPC

(95% CI)

LR+

LR−

Accuracy

(95% CI)

AUC

(95% CI)

SEN

(95% CI)

SPC

(95% CI)

LR+

LR−

Accuracy

(95% CI)

AST*

0.81

(0.72;0.88)

83.6

(72.5;91.5)

65.5

(45.7;82.1)

2.42

0.25

0.76

(0.66;0.84)

0.84

(0.75;0.90)

67.4

(52.5;80.1)

89.7

(78.8;96.1)

6.51

0.36

0.74

(0.64;0.82)

GGT*

0.85

(0.77;0.92)

67.2

(54.6;78.2)

93.1

(77.2;99.2)

9.74

0.35

0.76

(0.66;0.84)

0.83

(0.75;0.90)

69.4

(54.6;81.7)

86.2

(74.6;93.9)

5.03

0.36

0.73

(0.63;0.81)

CDT**

0.83

(0.74;0.90)

74.6

(62.5;84.5)

82.8

(64.2;94.2)

4.33

0.31

0.73

(0.63;0.81)

0.82

(0.74;0.89)

81.6

(68.0;91.2)

70.7

(57.3;81.9)

2.79

0.26

0.73

(0.63;0.81)

GGT–CDT***

0.88

(0.80;0.94)

71.6

(59.3;82.0)

93.1

(77.2;99.2)

10.39

0.30

0.76

(0.66;0.84)

0.89

(0.81;0.94)

77.6

(63.4;88.2)

86.2

(74.6;93.9)

5.62

0.26

0.75

(0.65;0.83)

AUDIT-C****

0.99

(0.94;1.00)

98.5

(92.0;100.0)

93.1

(77.2;99.2)

14.28

0.02

0.93

(0.86;0.97)

0.93

(0.86;0.97)

85.7

(72.8;94.1)

91.4

(81.0;97.1)

9.94

0.16

0.79

(0.70;0.86)

  1. *Cutoff points for AST and GGT are 40 U/L
  2. **Cutoff point for CDT – “all” group is 1.0%, “men” group is 1.0%, and “women” group is 0.8%
  3. ***Cutoff point for GGT–CDT – “all” group is 2.1114, “men” group is 3.1901, and “women” group is 1.9765
  4. ****Cutoff point for AUDIT-C – “all” group is score 4, “men” group is score 5, and “women” group is score 4. (The cutoff point was determined by ROC analyses in the sample)
  5. *****At risky drink (men > 14 drinks/week, women > 7 drinks/week)/reference population (men 14 drinks/week, women 7 drinks/week)
  6. AST = aspartic acid transaminase; AUC = area under the curve; AUDIT-C = Alcohol Use Disorder Identification Test Consumption alcohol use disorder identification test consumption; CDT = carbohydrate-deficient transferrin; GGT = gamma- glutamyltransferase; LR = likelihood ratios; SEN = sensitivity; SPC = specificity