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Table 3 Sensitivity analyses for associations between pharmacotherapy for ADHD in offspring and the hazard rate for depression-related specialty care visits in parents

From: Association between pharmacotherapy for ADHD in offspring and depression-related specialty care visits by parents with a history of depression

 

Parents, No.

Events, No.

Between-individual comparison a

Within-individual comparison b

HR (95% CI)

HR (95% CI)

Parents who were not diagnosed with ADHD or treated with ADHD medication

 Mothers

2806

8869

1.04 (0.95–1.15)

0.97 (0.88–1.06)

 Fathers

1237

3313

0.96 (0.85–1.08)

0.79 (0.67–0.93)

Parents who had only one ADHD affected child

 Mothers

3455

10,720

1.01 (0.92–1.12)

0.97 (0.90–1.06)

 Fathers

1553

3751

0.95 (0.84–1.07)

0.81 (0.70–0.94)

Parents whose partner were free of depression during follow-up

 Mothers

3716

12,350

1.00 (0.92–1.09)

0.99 (0.92–1.07)

 Fathers

1559

4166

0.96 (0.86–1.07)

0.79 (0.69–0.91)

On-medication period redefined by a four-month cut-off

 Mothers

3872

12,978

1.01 (0.93–1.10)

1.01 (0.94–1.08)

 Fathers

1733

4719

0.95 (0.86–1.05)

0.78 (0.69–0.88)

Extending on-medication period by 30 days

 Mothers

3872

12,978

1.00 (0.92–1.08)

0.98 (0.91–1.06)

 Fathers

1733

4719

0.96 (0.87–1.07)

0.80 (0.70–0.90)

Depression-related unplanned visits as outcome events

 Mothers

1694

1116

1.04 (0.82–1.33)

1.22 (0.86–1.73)

 Fathers

886

503

1.02 (0.83–1.25)

0.58 (0.35–0.94)

  1. HR Hazard ratio, CI confidence interval
  2. aBetween individual comparisons were adjusted for age of the offspring as a time-varying covariate, as well as measured time-constant covariates, including sex of the offspring, civil status, highest education achieved, and employment status of the parent at baseline
  3. bWithin individual comparisons were adjusted for age of the offspring as a time-varying covariate