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Table 2 Association between possible predictors (separated for four sets of possible predictors as determined in the methods section), treatment groups (EMC/TAU) and remission at endpoint

From: Predictors of the effectiveness of an early medication change strategy in patients with major depressive disorder

Possible predictor

Criteria

Odds ratio (Expo [β])

p-value

Bonferroni holm corrected p-value1

Age

treatment group

0.398

0.413

0.007

subtype

0.360

0.431

0.008

subtype*group

1.013

0.673

0.017

Sex

treatment group

0.398

0.457

0.010

subtype

0.760

0.807

0.050

subtype*group

1.303

0.724

0.025

Age of onset

treatment group

0.228

0.159

0.005

subtype

0.952

0.329

0.006

subtype*group

1.033

0.318

0.006

Prior medication

treatment group

1.481

0.484

0.013

subtype

7.600

0.087

0.005

subtype*group

0.183

0.031

0.004

Course of depression (1. episode/recurrent MDD)

treatment group

0.325

0.029

0.017

subtype

0.229

0.229

0.050

subtype*group

0.061

0.041

0.025

Melancholic MDD

treatment group

0.962

0.956

0.050

subtype

1.337

0.820

0.013

subtype*group

0.539

0.460

0.006

Anxious depression

treatment group

0.700

0.532

0.007

subtype

0.795

0.839

0.017

subtype*group

0.785

0.748

0.010

Atypical MDD

treatment group

0.275

0.019

0.004

subtype

0.174

0.174

0.005

subtype*group

5.339

0.032

0.005

MDD with Suicidality

treatment group

0.933

0.922

0.025

subtype

1.620

0.713

0.008

subtype*group

0.518

0.430

0.006

Comorbid axis I disorder

treatment group

0.491

0.202

0.008

subtype

0.712

0.761

0.025

subtype*group

0.617

0.617

0.017

Comorbid axis II disorder

treatment group

0.561

0.195

0.007

subtype

0.489

0.551

0.013

subtype*group

1.084

0.921

0.050

CIRS sum score

treatment group

1.601

0.506

0.010

subtype

1.352

0.175

0.006

subtype*group

0.778

0.119

0.006

  1. 1 in B-H correction, results are defined as significant (bold) if the p-value of the regression analysis is lower or equal as the B-H corrected p-value; * logistic regression analyses; MDD Major depressive disorder, CIRS Cumulative Illness Rating Scale