Early predictors of poor treatment response in patients with schizophrenia treated with atypical antipsychotics

BMC Psychiatry

Table 2 Mean PANSS total scores change over time (PANSS: Positive and Negative Syndrome Scale) and comparative analysis among group

Mean PANSS total scores	Group variable	N	Mean (SD)	Std. Error	95% Confidence Interval for Mean Lower bound Upper bound		F	P
Mean PANSS total scores at baseline (day 0)	Olanzapine	53	89.85 (22.29)	3.06	83.70	95.99
	Risperidone	28	94.39 (23.40)	4.42	85.32	103.46
	Paliperidone	30	84.67 (22.99)	4.20	76.08	93.25
	Total	111	89.59 (22.83)	2.17	85.30	93.89	1.33	0.27
Mean PANSS total scores at Week 1	Olanzapine	45	85.95 (20.88)	3.22	79.45	92.46
	Risperidone	26	95.31 (22.96)	4.50	86.03	104.58
	Paliperidone	29	81.69 (19.09)	3.54	74.43	88.95
	Total	100	87.19 (21.39)	2.17	82.88	91.50	3.03	0.053
Mean PANSS total scores at Week 2	Olanzapine	45	77.29 (20.25)	3.02	71.21	83.37
	Risperidone	26	91.23 (20.88)	4.09	82.80	99.66
	Paliperidone	29	78.79 (21.01)	3.90	70.80	86.79
	Total	100	81.35 (21.27)	2.13	77.13	85.57	4.08	0.02
Mean PANSS total scores at Week 3	Olanzapine	39	74.82 (21.27)	3.72	67.29	82.35
	Risperidone	26	87.00 (20.19)	3.956	78.85	95.15
	Paliperidone	29	76.90 (20.21)	3.753	69.21	84.58
	Total	94	78.83 (21.90)	2.26	74.34	83.32	2.67	0.08
Mean PANSS total scores at Week 4	Olanzapine	37	70.22 (23.62)	3.88	62.34	78.09
	Risperidone	25	84.24 (19.87)	3.98	76.04	92.44
	Paliperidone	27	74.19 (19.01)	3.66	66.66	81.71
	Total	89	75.36 (21.83)	2.31	70.76	79.96	3.30	0.04
Mean PANSS total scores at Week 8	Olanzapine	32	68.94 (24.43)	4.32	60.13	77.74
	Risperidone	25	82.60 (18.20)	3.64	75.09	90.11
	Paliperidone	24	70.42 (18.04)	3.68	62.80	78.03
	Total	81	73.59 (21.47)	2.39	68.84	78.34	3.41	0.04
Mean PANSS total scores at Week 12	Olanzapine	28	67.11 (18.22)	3.44	60.04	74.17
	Risperidone	25	79.20 (19.26)	3.85	71.25	87.15
	Paliperidone	18	72.17 (19.90)	4.69	62.27	82.06
	Total	71	72.65 (19.47)	2.31	68.04	77.26	2.68	0.08

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