Table 2 Association between use of acetaminophen by the mother during pregnancy and mental health outcomes at the age of 6 years (N = 3470)
Outcomes | Frequency of outcome according to use of acetaminophen during pregnancy N (%) | Crude analysis | Adjusted analysisa | p-value for sex – use of acetaminophen interaction termb | ||
|---|---|---|---|---|---|---|
Exposed n (%) | Not exposed n (%) | OR (95% CI) | OR (95% CI) | p | ||
6 years old | ||||||
Total SDQ (score ≥ 17 pts) | 102 (10.57) | 271 (10.82) | 0.97 (0.77–1.24) | 1.15 (0.88–1.50) | 0.313 | 0.454 |
Emotional symptoms (score ≥ 5 pts) | 137 (14.20) | 335 (13.37) | 1.07 (0.87–1.33) | 1.15 (0.91–1.46) | 0.232 | 0.046 |
Conduct problems (score ≥ 4 pts) | 119 (12.33) | 396 (15.81) | 0.75 (0.60–0.93) | 0.86 (0.68–1.10) | 0.222 | 0.572 |
Hyperactivity/inattention (score ≥ 7 pts) | 137 (14.20) | 344 (13.73) | 1.04 (0.84–1.29) | 1.10 (0.87–1.39) | 0.427 | 0.018 |
Peer relationship problems (score ≥ 4 pts) | 124 (12.85) | 366 (14.61) | 0.86 (0.69–1.07) | 1.08 (0.85–1.38) | 0.517 | 0.140 |
Prosocial behavior (score ≤ 4 pts) | 8 (0.83) | 33 (1.32) | 0.63 (0.29–1.36) | 0.63 (0.27–1.49) | 0.376 | 0.967 |
11 years old | ||||||
Total SDQ (score ≥ 17 pts) | 138 (14.39) | 342 (13.75) | 1.06 (0.85–1.30) | 1.19 (0.94–1.50) | 0.157 | 0.811 |
Emotional symptoms (score ≥ 5 pts) | 213 (22.21) | 473 (19.01) | 1.22 (1.01–1.46) | 1.20 (0.98–1.46) | 0.078 | 0.313 |
Conduct problems (score ≥ 4 pts) | 108 (11.26) | 343 (13.79) | 0.79 (0.63–1.00) | 0.93 (0.72–1.20) | 0.561 | 0.264 |
Hyperactivity/inattention (score ≥ 7 pts) | 165 (17.21) | 391 (15.72) | 1.12 (0.91–1.36) | 1.20 (0.96–1.49) | 0.112 | 0.797 |
Peer relationship problems (score ≥ 4 pts) | 131 (13.66) | 328 (13.18) | 1.04 (0.84–1.30) | 1.21 (0.95–1.53) | 0.123 | 0.781 |
Prosocial behavior (score ≤ 4 pts) | 8 (0.83) | 40 (1.61) | 0.52 (0.24–1.10) | 0.79 (0.36–1.75) | 0.565 | 0.151 |