Humanistic outcomes in treatment resistant depression: a secondary analysis of the STAR*D study

BMC Psychiatry

Table 3 Quality of life and functional impairment at Primary Visit^a for TRD and non-TRD patients

Endpoint	TRD	Non-TRD	Mean Difference TRD vs non-TRD	95% CI	P-value
Quality of Life, mean
Short form (SF-12) scores^c
Mental component	30.0	45.7	−15.7	−17, −14.4	<.0001
Physical component	47.7	48.9	−1.2	−2.1, −0.3	0.0126
Q-LES-Q General activities index	43.6	63.7	−20.1	−22.2, −18.1	<.0001
Functional impairment
WSAS score	23.4	11.3	12.0	10.9, 13.2	<.0001
WPAI, %^b
Activity impairment	54.5	30.5	24.0	20.8, 27.2	<.0001
Percent hours missed	19.6	9.5	10.1	6.4, 13.8	<.0001
Work impairment	43.0	19.2	23.8	19.7, 27.9	<.0001
Overall work impairment	52.9	24.9	28.0	23, 33	<.0001

^a The primary visit is the first visit in level 3 for TRD patients and the visit closest to 141 days from baseline visit and with a deviation ≤60 days for non-TRD patients
Least square means, 95% CIs, and p-values were obtained from a linear model adjusted for baseline of the variable, age category, gender, and baseline values of total severity score of comorbidity, Depression severity by HDRS17, and Depression severity by QIDS-SR16
^bWPAI scores are based on 7-day recall period
SFHS Short form health survey, Q-LES-Q Quality of life enjoyment and satisfaction, WSAS Work and social adjustment scale, WPAI Work productivity and activity impairment, TRD Treatment resistant depression, CI Confidence interval
^cRange of SF-12 scores reported: Mental Component 13.8 to 67.9; Physical Component 7.4 to 70.5. Lower score indicates poorer mental or physical health-related function and wellbeing

ISSN: 1471-244X