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Table 3 Quality of life and functional impairment at Primary Visita for TRD and non-TRD patients

From: Humanistic outcomes in treatment resistant depression: a secondary analysis of the STAR*D study

Endpoint TRD Non-TRD Mean Difference TRD vs non-TRD 95% CI P-value
Quality of Life, mean
 Short form (SF-12) scoresc
  Mental component 30.0 45.7 −15.7 −17, −14.4 <.0001
  Physical component 47.7 48.9 −1.2 −2.1, −0.3 0.0126
 Q-LES-Q General activities index 43.6 63.7 −20.1 −22.2, −18.1 <.0001
Functional impairment
 WSAS score 23.4 11.3 12.0 10.9, 13.2 <.0001
 WPAI, %b
  Activity impairment 54.5 30.5 24.0 20.8, 27.2 <.0001
  Percent hours missed 19.6 9.5 10.1 6.4, 13.8 <.0001
  Work impairment 43.0 19.2 23.8 19.7, 27.9 <.0001
  Overall work impairment 52.9 24.9 28.0 23, 33 <.0001
  1. a The primary visit is the first visit in level 3 for TRD patients and the visit closest to 141 days from baseline visit and with a deviation ≤60 days for non-TRD patients
  2. Least square means, 95% CIs, and p-values were obtained from a linear model adjusted for baseline of the variable, age category, gender, and baseline values of total severity score of comorbidity, Depression severity by HDRS17, and Depression severity by QIDS-SR16
  3. bWPAI scores are based on 7-day recall period
  4. SFHS Short form health survey, Q-LES-Q Quality of life enjoyment and satisfaction, WSAS Work and social adjustment scale, WPAI Work productivity and activity impairment, TRD Treatment resistant depression, CI Confidence interval
  5. cRange of SF-12 scores reported: Mental Component 13.8 to 67.9; Physical Component 7.4 to 70.5. Lower score indicates poorer mental or physical health-related function and wellbeing
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BMC Psychiatry

ISSN: 1471-244X

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