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Table 2 Demographics and baseline clinical characteristics of TRD and non-TRD patients

From: Humanistic outcomes in treatment resistant depression: a secondary analysis of the STAR*D study

Variable N TRD N Non-TRD P-Value
Age at entry to study; mean years (SD) 377 44.3 (11.97) 2090 41.8 (13.26) 0.0005
Age, years; (%) 0.0004
 18–34 98 26 734 35.1  
 35–49 145 38.5 744 35.6  
 50–64 122 32.4 512 24.5  
 65+ 12 3.2 100 4.8  
Gender; n (%) <.0001
 Female 193 51.2 1322 63.2  
 Male 184 48.8 769 36.8  
HDRS17 current score (transcribed); mean (SD) 377 24.4 (5.10) 2089 22.0 (4.80) <.0001
Depression severity by HDRS17; (%) <.0001
 Mild (score: 8–13) 0 0 3 0.1  
 Moderate (score:14–19) 63 16.7 703 33.7  
 Severe (score: 20–25) 164 43.5 920 44  
 Very severe (score:26+) 150 39.8 463 22.2  
QIDS-C current score (transcribed); mean (SD) 377 17.5 (3.19) 2089 15.8 (3.27) <.0001
Depression severity by QIDS-SR16; (%) <.0001
 No Depression (score:0–5) 0 0 25 1.2  
 Mild (score:6–10) 18 4.8 308 14.8  
 Moderate (score:11–15) 115 30.6 861 41.3  
 Severe (score:16–20) 168 44.7 693 33.3  
 Very severe (score:21+) 75 19.9 197 9.5  
QIDS-SR current score (transcribed); mean (SD) 376 17 (3.86) 2084 14.7 (4.25) <.0001
Total severity score of comorbid condition; mean (SD) 377 5.6 (4.43) 2091 4.3 (3.66) <.0001
  1. HDRS17 The Hamilton Rating Scale for Depression, QIDS-C Quick inventory of depressive symptomatology (clinician-rated), QIDS-SR Quick inventory of depressive symptomatology (self-rated), SD Standard deviation, TRD Treatment resistant depression