- Research article
- Open Access
Health-related quality of life in multiple sclerosis: temperament outweighs EDSS
BMC Psychiatry volume 18, Article number: 143 (2018)
The influence of personality on health-related quality of life in patients with multiple sclerosis has been the focus of previous studies showing that introversion and neuroticism were related with reduced health related quality of life. However, no data exist on the impact of temperament on quality of life in this patient group.
Between April 2014 and March 2016 139 multiple sclerosis patients were recruited from a specialized outpatient clinic of the general hospital of Vienna. Health-related quality of life was measured by “The Multiple Sclerosis International Quality of Life Questionnaire (MusiQol)”, temperament by “Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Questionnaire – Münster version” (briefTEMPS-M), and disability by the “Expanded disability status scale”. All patients underwent a diagnostic psychiatric semi-structured interview (MINI).
Known predictors (like disease duration, EDSS, psychiatric co-morbidities, immunomodulatory treatments) explain the proportion of variation in the outcome of MusiQol global index score in 30.9% in multi-variable linear regression analysis. It increased respectively to 40.3, 42.5, and 45.8% if adding the depressive, cyclothymic, or hyperthymic temperament to the list of variables. An increase of depressive and cyclothymic temperament scores significantly reduced global index score of MusiQol (p = 0.005, p = 0.002, respectively), while the hyperthymic temperament significantly raised it (p < 0.001).
In MS patients, the depressive and cyclothymic temperament predict a lower and hyperthymic temperament an increased health-related quality of life, independent of current disability status, immunomodulatory treatments, and affective co-morbidities.
Multiple sclerosis (MS) is a chronic demyelinating and neurodegenerative disorder of the central nervous system. It is characterized by clinical exacerbations alternating with episodes of complete or relative well-being . MS challenges patients to deal with its typically unpredictable clinical course and MS is known to have negative effects on quality of life and mental health. A high rate of psychiatric co-morbidities like anxiety and mood disorders can be found [2,3,4]. Further, in previous studies personality accentuations have been reported to be common in MS, which play a role in the disease course and influence quality of life [5,6,7]. Zarbo et al., for example, recently could show, that introversion and neuroticism are associated with lower health-related quality of life in MS and concluded that health related quality of life is largely influenced by these personality traits .
However, to our best knowledge, no studies were published, which focused on the impact of temperament on health related quality of life in MS, which can be seen as an individual’s core of behavior and affectivity, on which personality traits are acquired on top. While personality is influenced by personal experience, temperament is defined as an emotional, inherited, and temporally stable domain of personality [9, 10]. Based on the research of Emil Kraepelin , Akiskal  described five temperament types (i.e. depressive, cyclothymic, hyperthymic, irritable, and anxious temperament) . These temperament types represent healthy emotional reactivity patterns and stretch to the earliest subclinical presentations of affective disorders, always depending on whether a temperament is expressed in a predominant form . Only the study by Özkan et al. using TEMPS-A , investigated the influence of temperament, according to Akiskals concept, in MS previously. However, focusing on mood disorders, quality of life was not assessed in this study. They found that MS patients scored higher in the depressive, cyclothymic, irritable, and anxious domains than the control group . Studies using “Cloninger Temperament and Character Inventory” for temperament evaluation in MS patients found elevated levels of harm avoidance and lower levels of reward dependence and persistence as compared to healthy controls [6, 12]. The quality of life was not evaluated in these studies.
The aim of our study was therefore to evaluate the impact of different temperament types as defined by Akiskal et al.  on health-related quality of life in MS patients.
Between April 2014 and March 2016 patients were recruited from the outpatient MS clinic of the Medical University of Vienna and gave written informed consent to participate. Inclusion criteria were a diagnosis of multiple sclerosis according to the revised McDonalds criteria  and a minimum age of 18 years. Secondary progressive MS was defined as continuous worsening of EDSS in the absence of a relapse over a period of 12 months in patients formerly suffering from relapsing remitting MS. Patients suffering from clinical relevant psychiatric disorders, other than affective disorders, within 6 months from the inclusion time point were excluded.
After screening of 151 MS patients and exclusion of 12 patients due to psychiatric comorbidities, a final number of 139 MS patients were included.
The study was approved by the ethics committee of the Medical University of Vienna (EK1715/2013).
Evaluation of health-related quality of life
Health-related quality of life was evaluated by “The Multiple Sclerosis International Quality of Life questionnaire” (MusiQol) : a multidimensional, self-administered, patient-focussed questionnaire that refers to the last four weeks and consists of thirty-one items, describing nine dimensions of health-related quality of life (i.e. activities of daily living, psychological wellbeing, symptoms, relationship with friends, relationships with family, sentimental and sexual life, coping, rejection and relationship with healthcare system). All sub-scores and the global index score are linearly transformed with a maximum sum score of 100 with higher scores indicating a better health related quality of life. According to the manual’s procedure, calculation of global index score is only recommended for patients for whom all of nine dimensions could be calculated (a dimension’s value is set to missing if at least 50% of the items within the dimension are missing) .
Evaluation of temperament type
Temperament was evaluated by brief-TEMPS-M (Temperament Evaluation of Memphis, Pisa, Paris, and San Diego questionnaire – Münster version) : a short, self-administered questionnaire consisting of thirty-five items with a 5-point anchored Likert-type scale, assessing five types of temperaments as suggested by Akiskal et al. : the depressive, hyperthymic, cyclothymic, irritable, and anxious temperament.
Evaluation of psychiatric disorders
Evaluation of disability
The “Expanded disability status scale” (EDSS)  was used to assess disability in MS patients. The EDSS is an ordinal clinical rating scale, ranging from 0 to 10 with higher scores indicating more severe disability. Scoring is based on clinical neurological examination.
Categorical variables are described as counts and percentages. Continuous variables are described as medians and ranges due to the asymmetric distribution of most variables. The potential effect of each of five temperament scores on the MusiQoL global index score was investigated in five separate multi-variable linear regression models to correct for the influence of known predictors (disease duration, EDSS, psychiatric co-morbidities, immunomodulatory treatments). All temperament scores except hyperthymic exhibited a clearly right-skewed distribution such that these scores were transformed for use in the regression models using a logarithmic transformation with base 1.2. Thus, regression coefficients (reported with 95% confidence intervals) quantify the effect of a 20% temperament score increase on the global index score, while for hyperthymic temperament it quantifies the effect of a temperament score increase by one score point. The p-values for the five temperament scores are adjusted for multiple testing using the method of Bonferroni-Holm. For each model, we also report the R2 to quantify the proportion of variation in the outcome (global index score) that is explained by the variables in the respective model.
The strict application of the MusiQoL manual’s procedure assigns a missing value in the global index score if at least one of the nine dimensions is missing. This approach resulted in missing global score index values for 58 of 139 patients. In a sensitivity analysis, we therefore calculated the global index score not only for those patients with non-missing values for all nine dimensions, but for the 132 patients with at least five non-missing dimensions.
Each of MusiQoL dimensions 1 to 3 was investigated in the same manner as described above for the global index score. Dimensions 4 to 9, however, showed high percentages (30 to 60%) of patients obtaining full score precluding an investigation by linear regression models. Instead, we dichotomized each dimension to ‘full score’ versus ‘below full score’. For each dimension, the dichotomized score was investigated in a separate logistic regression model with the same four known predictors as above and each temperament score. The effect of the latter is quantified by an odds ratio. For each dimension the p-values corresponding to the five temperament scores are again adjusted for multiple testing using the method of Bonferroni-Holm. The importance of temperament scores is quantified using proportions of explained variation . Note that these are known to be considerably lower in general than R2 values in linear regression.
The reported p-values are the results of two-sided tests. P-values ≤0.05 were considered to be statistically significant. Since the global index score was the primary outcome and the nine dimensions were investigated in an exploratory manner, no correction for testing nine dimensions has been performed; p-values and confidence intervals have to be interpreted accordingly. All computations were carried out using SAS software Version 9.4 (SAS Institute Inc., Cary, NC, USA, 2012).
Demographic characteristics of included patients are shown in Table 1. Median scores of the brief-TEMPS-M were 11 (range 7–33), 11 (range 7–30), 22 (range 7–35), 12 (range 7–30), and 13 (range 7–27) in the depressive, cyclothymic, hyperthymic, irritable, and anxious temperament, respectively (Fig. 1).
Calculation of global index score strictly according to the MusiQol’s manual was done in 81 patients, showing a median of 81.1 (range 29.3–88.4). The proportion of variation in the outcome of MusiQol global index score that was explained by known predictors (disease duration, EDSS, psychiatric co-morbidities, immunomodulatory treatments) amounts to 30.9% in multi-variable linear regression analysis. This percentage is increased to 40.3, 42.5, or 45.8% if depressive, cyclothymic, or hyperthymic temperament was added to the list of variables. Irritative and anxious temperament had no statistically significant influence. An increase of depressive and cyclothymic temperament scores significantly reduced global index score (adj. p = 0.005, p = 0.002, respectively), while hyperthymic temperament significantly raised it (p < 0.001). A detailed listing of these results is given in Table 2. Figure 1 depicts the association of global index score with each temperament score. See Additional file 1: Table S1 for a sensitivity analysis covering 132 patients.
We also analyzed each of the nine dimensions of MusiQol separately.
An increase of cyclothymic and anxious temperament score by 20% reduced the score of “activities of daily living” on average by − 2.8 score points (95% CI -4.6 to − 1.1, p = 0.002) and − 2,6 (95% CI -4.5 to − 0.7, p = 0.008), respectively. After adjusting for testing five temperaments, this was still statistically significant (p = 0.008, p = 0.0032, respectively). The score of “psychosocial wellbeing” was statistically significantly increased by hyperthymic temperament (p < 0.001) and decreased by depressive (p < 0.001), cyclothymic (p < 0.001), and anxious (p < 0.001) temperament. Table 3 gives detailed information on these results.
Logistic regression analysis was performed for the remaining MusiQol dimensions. The proportion of variation in the outcome of “relationship with family”, “sentimental and sexual life”, “coping”, “rejection”, and “relationship with health care system”, that is explained by known predictors (EDSS, disease duration, psychiatric co-morbidities, MS-specific medication), amounts to 5.9, 1.9, 5.2, 10.4, and 13.6%, respectively, and was increased to 10.7, 13.6, 10.7, 17.2, and 16.4%, respectively, after adding hyperthymic temperament to the list of variables. A unit increase in the hyperthymic temperament score reduced the odds of obtaining a full score in “sentimental and sexual life” and “rejection” by 12% (OR = 0.88, adj. p = 0.001) and 11% (OR = 0.89, adj. p = 0.014), respectively. An increase of depressive and cyclothymic temperament score by 20% increased the odds of obtaining a full score in “rejection” by 50% (OR = 1.50, adj. p = 0.005) and 42% (OR = 1.42, adj. p = 0.031), respectively. An increase of depressive and cyclothymic temperament scores also significantly increased the odds of obtaining a full score in “relationship with health care system” (adj. p = 0.001 and 0.004, respectively). See Additional file 2: Table S2 for more results.
To our best knowledge, this is the first study investigating the impact of affective temperament types on health-related quality of life in MS-patients. Analyzing data of 139 MS-patients, we found that the depressive and cyclothymic temperament predicted a lower and the hyperthymic temperament an increased health-related quality of life in MS patients, independent of current disability status. Accordingly, dealing with physical disability based on predetermined temperamental attributes rather than disability itself seems to affect HRQol in MS. Besides, the statistically significant effect of temperament types on HRQoL was also independent of co-morbid mood disorders and immunomodulatory treatments, both factors known to influence HRQoL of MS patients . Depression and fatigue were independently associated with reduced HRQoL in another study  and the benefit of immunomodulation on HRQoL was most prominent in MS patients suffering from marked fatigue .
The high impact of affective temperaments on health-related quality of life highlights their alleged role as an individual’s core of behavior and affectivity and as earliest subclinical phenotypes of affective disorders . This especially applies to the depressive and cyclothymic temperament, when considering that depressive mood ranks among the most common complaints throughout all MS stages with a well-documented negative impact on health-related quality of life . Attributes of the depressive temperament comprise self-denying, low energy-level, negativism, introversion, unhappiness, and always seeing the dark side of things . When facing an unpredictable potentially disabling disease like MS these attributes are certainly not helpful in enhancing health related quality of life. In cyclothymic temperament, rapid shifts in mood and energy levels may predispose to distress and reduced health related quality of life. Surprisingly, statistically significant negative effects of the anxious temperament were only seen in 2 out of 9 MusiQol subscales (i.e., “activities of daily living”, “psychosocial wellbeing”) and not in global index score. Anxiety disorders in their subclinical manifestations may not affect social relationships and other dimensions of health-related quality of life that contribute to MusiQol global index score. According to Akiskal, outstanding characteristics of individuals with hyperthymic temperament are “cheerful, overoptimistic or exuberant, naïve, overconfident, self-assured, boastful, bombastic and grandiose” . This almost over-boarding positive self-assessment may explain the positive impact on overall health-related quality of life and, as this behavior may offend other people, also the negative influence on the MusiQol subscales of “sentimental and sexual life” and “rejection”. MS patients with higher depressive and cyclothymic temperament scores surprisingly reported an increased health related quality of life in the subscales “rejection” and “relationship with health care system”, maybe because they focus more on themselves than on the social environment and therefore don’t experience “rejection”. The positive relationship with the health care system may exist, as these patients might be seen as more vulnerable and needy to doctors, thus, receiving more attention from them. The irritable temperament does not seem to affect health-related quality of life at all, while irritability was found to be a key symptom of interictal dysphoric disorder in epilepsy .
Previous studies reporting not on temperament, but on MS patients´ personality characteristics measured various personality traits, used different screening tools, and except for one , did not evaluate an association to health-related quality of life, thus, making results barely comparable with ours [5, 6, 11, 12, 26, 27]. Only Zarbo reported an association between personality and health-related quality of life in MS patients, but these results referred to the Five Factor model, underpinning a negative influence of introversion and neuroticism . Moreover, neurotic MS patients were more worried about their future, experienced higher levels of anxiety and depression , and were more prone to risky treatment options .
Our study has some limitations. First, the number of patients for our final analysis of the MusiQol global index score was lower than expected. However, a sensitivity analysis covering 132 patients supports the validity of our result. Second, we did not collect data from a healthy control group, as we preferred evaluating health-related quality of life with an MS specific questionnaire not applicable for a healthy control group. Another limitation concerns the cross-sectional design of our study and that possibly confounding factors (like cognition and fatigue) were not assessed systematically.
In conclusion, hyperthymic temperament in MS patients could explain an increased and depressive and cyclothymic temperament a reduced health-related quality of life, independent of current disability status, co-morbid mood-disorders and immunomodulatory treatments. Prospective evaluation of temperament types in MS patients could help to identify patients early, who need more biopsychosocial support to booster quality of life. This includes consecutive initiation of early and sufficient pharmacological as well as non-pharmacological treatment, especially psychotherapy. Evaluating temperaments in MS may also support clinicians to better understand coping strategies, treatment adherence, and decisions on accepting possibly risky treatment options.
Expanded disability status scale
Health related quality of life
Mini International Neuropsychiatric Interview
The Multiple Sclerosis International Quality of Life Questionnaire
Severity of dependence scale
Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Questionnaire – Münster version
Compston A, Coles A. Multiple sclerosis. Lancet. 2008;372(9648):1502–17.
Benedict RH, Wahlig E, Bakshi R, Fishman I, Munschauer F, Zivadinov R, et al. Predicting quality of life in multiple sclerosis: accounting for physical disability, fatigue, cognition, mood disorder, personality, and behavior change. J Neurol Sci. 2005;231(1–2):29–34.
Goretti B, Portaccio E, Zipoli V, Hakiki B, Siracusa G, Sorbi S, et al. Coping strategies, psychological variables and their relationship with quality of life in multiple sclerosis. Neurol Sci. 2009;30(1):15–20.
Yamout B, Issa Z, Herlopian A, El Bejjani M, Khalifa A, Ghadieh AS, et al. Predictors of quality of life among multiple sclerosis patients: a comprehensive analysis. Eur J Neurol. 2013;20(5):756–64.
Benedict RH, Priore RL, Miller C, Munschauer F, Jacobs L. Personality disorder in multiple sclerosis correlates with cognitive impairment. J Neuropsychiatry Clin Neurosci. 2001;13(1):70–6.
Christodoulou C, Deluca J, Johnson SK, Lange G, Gaudino EA, Natelson BH. Examination of Cloninger's basic dimensions of personality in fatiguing illness: chronic fatigue syndrome and multiple sclerosis. J Psychosom Res. 1999;47(6):597–607.
Merkelbach S, Konig J, Sittinger H. Personality traits in multiple sclerosis (MS) patients with and without fatigue experience. Acta Neurol Scand. 2003;107(3):195–201.
Kraepelin E. 100 years of psychiatry. Vertex. 2010;21(91):317–20.
Akiskal KK, Akiskal HS. The theoretical underpinnings of affective temperaments: implications for evolutionary foundations of bipolar disorder and human nature. J Affect Disord. 2005;85(1–2):231–9.
Akiskal HS, Mendlowicz MV, Jean-Louis G, Rapaport MH, Kelsoe JR, Gillin JC, et al. TEMPS-A: validation of a short version of a self-rated instrument designed to measure variations in temperament. J Affect Disord. 2005;85(1–2):45–52.
Ozkan A, Altinbas K, Koc ER, Sen HM, Ozisik Karaman HI. Affective temperament profiles in patients with multiple sclerosis: association with mood disorders. Noro Psikiyatr Ars. 2016;53(4):311–6.
Gazioglu S, Cakmak VA, Ozkorumak E, Usta NC, Ates C, Boz C. Personality traits of patients with multiple sclerosis and their relationship with clinical characteristics. J Nerv Ment Dis. 2014;202(5):408–11.
Polman CH, Reingold SC, Banwell B, Clanet M, Cohen JA, Filippi M, et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol. 2011;69(2):292–302.
Flachenecker P, Vogel U, Simeoni MC, Auquier P, Rieckmann P. MusiQol: international questionnaire investigating quality of life in multiple sclerosis: validation results for the German subpopulation in an international comparison. Nervenarzt. 2011;82(10):1281–9.
Erfurth A, Gerlach AL, Hellweg I, Boenigk I, Michael N, Akiskal HS. Studies on a German (Munster) version of the temperament auto-questionnaire TEMPS-A: construction and validation of the briefTEMPS-M. J Affect Disord. 2005;85(1–2):53–69.
Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, et al. The Mini-international neuropsychiatric interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry. 1998;59(Suppl 20):22–33. quiz 4-57
American Psychiatric Association. Diagnostic and statistical manual of mental disorders: DSM-IV-TR. Washington: American Psychiatric Association; 2000 https://0-doi-org.brum.beds.ac.uk/10.1176/appi.books.9780890423349.
Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology. 1983;33(11):1444–52.
Heinze G, Schemper M. Comparing the importance of prognostic factors in cox and logistic regression using SAS. Comput Meth Prog Bio. 2003;71(2):155–63.
Nourbakhsh B, Julian L, Waubant E. Fatigue and depression predict quality of life in patients with early multiple sclerosis: a longitudinal study. Eur J Neurol. 2016;23(9):1482–6.
Planche V, Moisset X, Morello R, Dumont E, Gibelin M, Charre-Morin J, et al. Improvement of quality of life and its relationship with neuropsychiatric outcomes in patients with multiple sclerosis starting treatment with natalizumab: a 3-year follow-up multicentric study. J Neurol Sci. 2017;382:148–54.
von Zerssen D, Akiskal HS. Personality factors in affective disorders: historical developments and current issues with special reference to the concepts of temperament and character. J Affect Disord. 1998;51(1):1–5.
Marrie RA, Reingold S, Cohen J, Stuve O, Trojano M, Sorensen PS, et al. The incidence and prevalence of psychiatric disorders in multiple sclerosis: a systematic review. Mult Scler. 2015;21(3):305–17.
Erdogan Taycan S, Taycan O. Affective temperament profiles and clinical correlates in patients with epilepsy: a link from mood disorders. J Affect Disord. 2014;164:1–4.
Zarbo IR, Minacapelli E, Falautano M, Demontis S, Carpentras G, Pugliatti M. Personality traits predict perceived health-related quality of life in persons with multiple sclerosis. Mult Scler. 2016;22(4):551–8.
Benedict RH, Wahlig EL, Topciu RA, Englert J, Schwartz E, Chapman B, et al. Personality traits in women with multiple sclerosis: discrepancy in patient/partner report and disease course. J Psychosom Res. 2009;66(2):147–54.
Benedict RH, Hussein S, Englert J, Dwyer MG, Abdelrahman N, Cox JL, et al. Cortical atrophy and personality in multiple sclerosis. Neuropsychology. 2008;22(4):432–41.
Tur C, Tintore M, Vidal-Jordana A, Bichuetti D, Nieto Gonzalez P, Arevalo MJ, et al. Risk acceptance in multiple sclerosis patients on natalizumab treatment. PLoS One. 2013;8(12):e82796.
The authors thank Marcus Meisel for editing the English text.
This research was partly supported by an unrestricted grant of the Austrian Ministry of Health (BIG-WIG) and the Vienna MS Society. As the grant was unrestricted, the funding bodies were not involved in the design of the study, collection, analysis, interpretation of data or writing the manuscript.
Availability of data and materials
The datasets supporting the conclusion of this article are included within this article. The datasets used and analysed during the current study are available from the corresponding author on reasonable request.
Ethics approval and consent to participate
The study was approved by the ethics committee of the Medical University of Vienna (EK1715/2013) and all patients gave written informed consent to participate. The study was conducted under the terms and conditions of the Declaration of Helsinki.
The authors declare that they have no competing interests.
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Table S1. Linear regression analysis showing the effect of temperament types on MusiQol Global Index Score (sensitivity analysis, N = 132). (DOCX 100 kb)
Table S2. Logistic regression analysis showing the effect of temperament types on MusiQol Dimensions 4–9; each dimension dichotomized to ‘full score’ versus ‘below full score’. (DOCX 15 kb)
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Salhofer-Polanyi, S., Friedrich, F., Löffler, S. et al. Health-related quality of life in multiple sclerosis: temperament outweighs EDSS. BMC Psychiatry 18, 143 (2018). https://0-doi-org.brum.beds.ac.uk/10.1186/s12888-018-1719-6
- Multiple sclerosis
- Health-related quality of life