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Table 2 Differences between different factors of anxiety/depression and non-anxiety/depression patients

From: Anxiety and depression in primary Sjögren’s syndrome: a cross-sectional study

Clinical characteristics

non-anxiety

Anxiety

p

non-depression

depression

p

Age, mean ± sd yearsa

50.08 ± 11.90

51.44 ± 12.90

0.508

49.69 ± 11.96

51.12 ± 12.68

0.228

Gender, female, no. (%)b

100(94.3)

55 (96.3)

0.878

97(96)

55 (93.2)

0.679

Marital status, no. (%)b

  

1.000

  

0.401

 Married

100 (94.3)

51 (94.4)

 

97 (96)

54 (91.5)

 

 Other marital status

6 (5.7)

3 (5.6)

 

4 (4)

5 (8.5)

Education, years, no. (%)a

12.43 ± 4.42

11.72 ± 4.16

0.327

13.00 ± 3.96

10.81 ± 4.62

0.002*

Employment status, no. (%)b

  

0.064

  

0.049*

 Employed

53 (50)

18 (33.3)

 

51 (50.5)

20 (33.9)

 

 Unemployed

53 (50)

36 (66.7)

 

50 (49.5)

39 (66.1)

Income/person/year, yuan, no. (%)b

  

0.423

  

0.094

  < 15,000 yuan

34 (32.1)

21 (38.9)

 

31 (30.7)

24 (40.7)

 

 15,000-33,000 yuan

36 (34)

13 (24.1)

 

37 (36.6)

12 (20.3)

  ≥ 33,000 yuan

36 (34)

20 (37)

 

33 (32.7)

23 (39)

Type of medical insurance, n (%)b

  

0.749

  

0.660

 With basic medical insurance

96 (90.6)

50 (92.6)

 

91 (90.1)

55 (93.2)

 

 Self-pay

9 (8.5)

4 (7.4)

 

9 (8.9)

4 (6.8)

 Other

1 (0.9)

0 (0)

 

1 (1)

0 (0)

Disease duration, mean ± sd yearsa

4.48 ± 5.61

4.53 ± 5.15

0.957

4.30 ± 4.72

4.83 ± 6.53

0.557

VAS pain (range 0–10), mean ± sda

2.12 ± 2.51

2.83 ± 2.98

0.127

2.35 ± 1.95

3.07 ± 2.99

0.016*

ESR, mean ± sd mm/ha

28.10 ± 21.38

35.87 ± 28.47

0.085

27.10 ± 20.04

36.78 ± 29.10

0.027*

OSDI, mean ± sda

25.07 ± 22.40

37.15 ± 28.28

0.008*

23.82 ± 20.81

38.26 ± 29.14

0.001*

RF positivity, yes, no. (%)b

29 (46)

22 (55)

0.422

30 (49.2)

21 (50)

1.000

Hospitalization, yes, n (%)b

68 (64.2)

40 (74.1)

0.218

68 (67.3)

40 (67.8)

1.000

Family history, yes, n (%)b

15 (14.2)

8 (14.8)

1.000

17 (16.8)

6 (10.2)

0.351

Comorbid conditions, yes, n (%)b

66 (62.3)

36 (66.7)

0.607

61 (60.4)

41 (69.5)

0.307

ESSDAIa

9.16 ± 7.73

10.48 ± 6.37

0.281

8.73 ± 7.35

11.10 ± 7.03

0.047*

IgG (g/L)a

19.05 ± 6.72

18.72 ± 6.60

0.806

18.99 ± 6.54

18.84 ± 6.85

0.909

C3 (g/L)a

0.80 ± 0.26

0.82 ± 0.28

0.781

0.80 ± 0.24

0.82 ± 0.30

0.632

C4 (g/L)a

0.18 ± 0.07

0.17 ± 0.06

0.627

0.18 ± 0.66

0.17 ± 0.06

0.552

ANA ≥1: 320b

61 (91)

35 (92.1)

1.000

60 (93.8)

36 (87.8)

0.481

Anti-SSA ≥ 200 RU/mLb

54 (80.6)

31 (81.6)

1.000

50 (78.1)

35 (85.4)

0.449

Anti-SSB ≥ 20 RU/mLb

32 (47.8)

21 (55.3)

0.544

29 (45.3)

24 (58.5)

0.231

  1. VAS visual analog scale, ESR erythrocyte sedimentation rate, RF rheumatoid factor, HADS hospital anxiety and depression scale, ESSDAI EULAR Sjögren’s syndrome disease activity index, ANA antinuclear antibodies, IgG immunoglobulin G, C3 complement C3, C4 complement C4, OSDI the ocular surface disease index.* = p<0.05; a = t-tests; b = χ2 analyses