Fig. 1

Regional GM increases among participants receiving CRT versus TAU. Increases in GM volume in the CRT and TAU groups, as assessed using voxel-based analysis. We detected areas where the CRT group’s GM volume growth was significantly greater than that of the TAU group (uncorrected P < .005 in 200 or more contiguous voxels). Statistical parametric mapping projections were then superimposed onto representative transaxial (z = − 21), sagittal (x = 35), and coronal (y = − 21) magnetic resonance images. Abbreviations: CRT, cognitive remediation therapy; GM, gray matter; L, left; R, right; TAU, treatment as usual