Switching (n analysed)a | Initiating (n analysed)a | P-value: switching vs initiating | Totalb (n) | |
---|---|---|---|---|
Characteristics of current depressive episode | ||||
Treating physician (% of patient group) | (247) | (910) | < 0.001 | (1159) |
General practitioner | 73.3 | 86.4 | 83.6 | |
Psychiatrist | 26.7 | 13.6 | 16.4 | |
Duration of episode (%)c | (247) | (910) | < 0.001 | (1157) |
< 1 week | 0.4 | 1.9 | 1.6 | |
1–2 weeks | 2.8 | 6.7 | 5.9 | |
2–4 weeks | 14.6 | 23.2 | 21.3 | |
4–8 weeks | 17.4 | 20.4 | 19.8 | |
> 8 weeks | 64.8 | 47.8 | 51.4 | |
Significant symptoms of anxiety (%)d | 74.5 (247) | 59.3 (910) | < 0.001 | 62.6 (1158) |
Symptoms treated with anxiolytics (%) | 53.1 (130) | 38.6 (376) | 0.004 | 42.2 (507) |
Questionnaire scores, mean ± SD | ||||
PHQ-9 | 18.4 ± 5.3 (198) | 17.4 ± 5.3 (740) | 0.014 | 17.6 ± 5.3 (940) |
CGI-S | 4.4 ± 1.0 (246) | 4.1 ± 1.0 (908) | < 0.001 | 4.2 ± 1.0 (1155) |
MADRSe | 32.5 ± 7.1 (66) | 32.9 ± 7.2 (124) | 0.724 | 32.7 ± 7.1 (190) |
SDS | ||||
Total score | 20.6 ± 6.6 (147) | 18.9 ± 6.7 (601) | 0.004 | 19.2 ± 6.8 (750) |
Work/school disruption | 6.7 ± 2.7 (150) | 6.1 ± 2.8 (614) | 0.020 | 6.3 ± 2.8 (766) |
Social life/leisure activities’ disruption | 7.0 ± 2.4 (179) | 6.4 ± 2.5 (704) | 0.003 | 6.6 ± 2.5 (885) |
Family life/home duties’ disruption | 7.0 ± 2.4 (179) | 6.4 ± 2.5 (701) | 0.001 | 6.5 ± 2.5 (882) |
WPAIf | 66.0 ± 23.5 (194) | 59.9 ± 24.9 (740) | 0.002 | 61.1 ± 24.8 (936) |
ASEX | ||||
Total score | 22.2 ± 5.8 (169) | 21.2 ± 5.7 (623) | 0.031 | 21.4 ± 5.7 (793) |
Sexual dysfunction (%) | 84.6 (188) | 80.3 (695) | 0.182 | 81.1 (884) |
SF-12 | (190) | (720) | (912) | |
PCS | 40.6 ± 11.4 | 46.4 ± 12.0 | < 0.001 | 45.2 ± 12.1 |
MCS | 26.8 ± 9.0 | 26.4 ± 9.2 | 0.598 | 26.5 ± 9.2 |
EQ-5D utility scoreg | 0.5 ± 0.3 (48) | 0.6 ± 0.3 (227) | 0.044 | 0.5 ± 0.3 (276) |
Other current illnesses | ||||
Mental-health disorders other than depression (%) | (247) | (910) | (1159) | |
Alcohol abuse or dependence | 1.6 | 3.0 | 0.245 | 2.7 |
Other abuse disorders | 1.2 | 1.3 | 1.000 | 1.3 |
Somatoform disorders | 10.5 | 7.0 | 0.069 | 7.9 |
Eating disorders (anorexia, bulimia) | 10.5 | 7.5 | 0.119 | 8.1 |
Other | 0.0 | 0.8 | 0.357 | 0.6 |
Functional syndromes (%) | (247) | (910) | (1159) | |
Chronic pain | 23.9 | 14.7 | < 0.001 | 16.7 |
Chronic fatigue | 17.0 | 15.9 | 0.685 | 16.1 |
Fibromyalgia | 13.0 | 5.2 | < 0.001 | 6.8 |
Premenstrual syndrome | 4.9 | 3.1 | 0.174 | 3.5 |
Sleep disorders | 29.1 | 27.9 | 0.701 | 28.2 |
Other | 2.4 | 2.9 | 0.716 | 2.8 |
Previous depressive episodes | ||||
History of depression (%) | ||||
Previous episode | 72.0 (246) | 52.4 (910) | < 0.001 | 56.6 (1157) |
Episode within previous 12 months if previous episode | 33.9 (177) | 22.4 (477) | 0.003 | 25.5 (655) |
Antidepressant treatment if previous episode | 91.0 (177) | 77.1 (476) | < 0.001 | 80.9 (654) |
Previous hospitalization for depression | 15.3 (177) | 6.5 (477) | < 0.001 | 8.9 (655) |
Remission of previous episode | 72.3 (177) | 87.2 (477) | < 0.001 | 83.2 (655) |
Previous suicide attempt | 18.1 (177) | 11.3 (477) | 0.023 | 13.1 (655) |