|  |  | Lead time to lithium discontinuation | |
---|---|---|---|---|
n (%) | Years, mean (SD) | Years, median (min-max) | ||
1. | Perceived or actual lack of effectiveness | 90 (24.6) | 2.3 (4.9) | 1.1 (0.04-39.9) |
2. | Non-adherence | 85 (22.4) | 2.9 (3.6) | 1.2 (0.1-15.0) |
3. | Diarrhoea | 49 (13.2) | 1.6 (2.2) | 0.7 (0.02-10.5) |
4. | Tremor | 45 (12.1) | 3.7 (5.4) | 1.6 (0.02-23.3) |
5. | Weight gain | 35 (9.4) | 2.6 (3.3) | 1.3 (0.1-12.9) |
6. | Nephrogenic diabetes insipidus, polyuria, polydipsia | 32 (8.6) | 4.8 (5.5) | 2.7 (0.1-20.6) |
7. | Emotional blunting | 24 (6.5) | 2.2 (1.9) | 1.8 (0.1-6.4) |
8. | Fatigue | 22 (5.9) | 2.6 (4.8) | 0.4 (0.02-17.3) |
9. | Nausea | 21 (5.7) | 0.5 (0.5) | 0.3 (0.02-1.6) |
10. | Creatinine increase, Li-nephropathy | 20 (5.4) | 17.2 (11.2) | 17.0 (0.1-38.8) |