Study ID | Pre randomization /eligibility | Patients | Interventions | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Author | Year | Condition | Previous episodes | Criteria used to measure relapse | Previous pharmacology interventions | N | Agea | Male (N/%) | Previous episodesa | % on ADM at baseline | Mean age of first onseta | Groups (n/dropouts) | Form of intervention | N(Number of sessions, frequency, Mean duration + boost sessions) | Length of Follow-Up(months) |
Bockting | 2005 | recurrent MDD, in remission for 10 weeks - 2 years | 2 + recent episodes in the previous 5 years | SCID-I | NR | 187 | 44.7/9.5 | 46/27 | 3.5/3.8 | 51 | 28.4/12.5 | CBT:97/16 | group | 8,weekly,2 h | 24 |
Control(TAU):90/6 | Â | Â | |||||||||||||
Bondolfi | 2010 | recurrent MDD, in remission for 3 + months | 3 + episodes (2 in the past 5 years and at least one in the past 2 years) | SCID | a history antidepressants treatment but off medication for 3 + months before enrolment. | 60 | 47.5(24–66) | 17/28 | 4(3–14) | 30 | 24.5(8–55) | MBCT:31/4 | group | 8,weekly,2 h + 4 sessions each 3 months | 14 |
Control(TAU):29/1 | Â | Â | |||||||||||||
Fava | 1994 | primary MDD, in full remission | NR | RDC-defined MDE | successfully response to antidepressant drugs according to a standardized protocol | 40 | 43.7/2.3 | 16/40 | NR | 100 | NR | CBT:20/0 | individual | 10,every other week,40Â min | 24 |
Control(PLA):20/0 | Â | Â | |||||||||||||
Fava | 1998 | MDD, in full remission for 10 week + | 3 or 3 + episodes | RDC-defined MDE | successfully response to antidepressant drugs according to a standardized protocol. | 40 | 46.1/3.7 | 13/32.5 | 3.6/0.8 | 100 | NR | CBT:20/0 | individual | 10,every other week,30 min | 24 |
Control(PLA):20/0 | Â | Â | |||||||||||||
Godfrin | 2010 | MDD, in remission for 8 + weeks | 3 or 3 + episodes | DSM-IV diagnosis of MDE | No special | 106 | 45.7/10.5 | 20/19 | NR | 76.4 | 29.8/10.2 | MBCT:52/18 | group | 8,weekly, 2.75 h + homework exercises (meditation practices) for 45 + min/d | 14 |
Control(TAU):54/12 | Â | Â | |||||||||||||
Hollandare | 2013 | MDD, in partial remission | 1 + episodes in the previous 5 years | SCID | No special | 84 | 45.3/12.8 | 13/15 | 5.96/9.1 | 50 | NR | CBT:42/10 | individual | 16 internet modules + general e-mails for 10 weeks | 24 |
Control(PLA)::42/7 | Â | Â | |||||||||||||
Kuyken | 2008 | recurrent MDD, in full or partial remission | 3 or 3 + episodes | SCID | on a continuing dose of m-ADM for 6 + months | 123 | 49.2/11.2 | 29/24 | 6.4/3.0 | 100 | 26.2/12.1 | MBCT-TS:61/9 | group | 8,weekly,2 h + 4 sessions | 15 |
m-ADM:62/10 | Â | Â | |||||||||||||
kuyken | 2015 | recurrent MDD, in full or partial remission | 3 or 3 + episodes | SCID | on a continuing dose of m-ADM for 6 + months | 424 | 49.5/12.5 | 99/23 | 46% 6 + | 100 | 24.9/12.4 | MBCT-TS:212/23 | group | 8,weekly, 2.25 h + 4 refresher sessions/3 months | 24 |
m-ADM:212/18 | Â | Â | |||||||||||||
Ma and Teasdale | 2004 | MDD, in remission for 12 + weeks | 2 or 2 + episodes in the previous 5 years | modeled on the SCID | a history antidepressants treatment but off medication for 3 + months before enrolment. | 75 | 44.5/9.0 | 18/24 | 3/2.0 | 100 | 30.6/12.4 | MBCT:37/6 | group | 8,weekly, 2.75 h + homework exercises | 13 |
Control(TAU):38/1 | Â | Â | |||||||||||||
Paykel | 1999 | MDD, in remission for 2–18 months | residual symptoms | DSM-III-R criteria for MDD for at least 1 month AND Minimum symptom score | all on a history antidepressants treatment | 158 | 43.4/10.5 | 80/51 | 37% 3 + | 100 | NR | CBT:80/19 | individual | 16 sessions over 20 weeks + 2 sessions 6 and 14 weeks later | 15.8 |
Control(PLA):78/12 | Â | Â | |||||||||||||
Segal | 2010 | MDD, in remission for 7+ months | 3 + episodes | 16 + on the HRSD-17 assessed twice then criteria for MDD measured with SCID | all on a history antidepressants treatment | 54 | 44.1/11 | 31/37 | 4.7/2.3 | 55 | 31/11.6 | MBCT:26/5 | group | 8,weekly,2 h + option 1 h/month mindfulness mediation class | 18 |
m-ADM:28/7 | Â | Â | |||||||||||||
Stangier | 2013 | MDD, in full remission | 3 or 3 + episodes | DSM-IV diagnosis of MDE (LIFE) | NR | 180 | 48.6/11.6 | 50/27.8 | 7.4/8.3 | 74.8 | 30.9/12.4 | Maintenance CBT: 90/15 | individual | 16,NR,50 min | 12 |
Manualized psychoeducation: 90/31 | individual | 16,NR,20Â min | |||||||||||||
Teasdale | 2000 | MDD, in remission(0-24 months) | 3 + episodes (2 in the past 5 years and at least one in the past 2 years) | SCID | a history antidepressants treatment but off medication for 3 + months before enrolment. | 145 | 43.3/10.3 | 35/24 | 3.3/3.0 | 100 | 26.8/10.2 | MBCT:76/13 | group | 8,weekly,2 h + 4 more sessions over trial duration | 12 |
Control(TAU):69/0 | Â | Â | |||||||||||||
Teismann | 2014 | MDD, in partial remission | NR | SCID | No special | 60 | 47.1/11.8 | 17/28 | 22.45% 5 + | 40 | NR | CBT:31/2 | group | 11,weekly,90Â min | 12 |
WL:29/5 | Â | Â | |||||||||||||
Wilkinson | 2009 | MDD, in remission for 2 + months | NR | MADRS score of 10 + at 6/12 months | Received antidepressant medication | 45 | 74.0/7.3 | 17/38 | 3.0/1.9 | 100 | NR | CBT:22/4 | group | 8,NR,90 min | 12 |
Control(PLA):23/5 | Â | Â | |||||||||||||
Williams | 2014 | MDD, in remission for 8+ weeks | 3 or 3 + episodes | SCID | NR | 164 | 43.4/12 | 76/28 | 77% 5 + | 44 | 21.3/10.7 | MBCT:108/9 | group | individual pre class interview + 8,weekly,2 h + follow-up classes taking place 6 weeks and 6 months in the follow-up | 12 |
Control(TAU):56/3 | Â | Â |