Gray matter morphological anomalies in the cerebellar vermis in first-episode schizophrenia patients with cognitive deficits

Table 1 Demographic and clinical characteristics of three groups

Demographics	HCs	SZ-NCD	SZ-CD	P
	10 M:11 F	7 M:11 F	11 M:5 F	0.205
	Mean ± SD	Mean ± SD	Mean ± SD
Age(years)	22.38 ± 3.94	24.5 ± 6.70	22.63 ± 6.71	0.71
Education(years)	13.33 ± 1.83	12.39 ± 2.06	12.16 ± 2.64	0.78
WAIS-Digital	–	71.53 ± 1.61	58.69 ± 12.32	0.02*
WAIS-Information	–	18.92 ± 5.13	15.1 ± 4.26	0.03*
Duration of illness (months)	–	8.25 ± 5.69	8.27 ± 4.31	0.83
CPZ equivalents	–	238.89 ± 104.16	375.12 ± 328.43	0.14
SAPS total	–	18.06 ± 8.62	16.23 ± 8.46	0.11
SANS total	–	21.11 ± 23.74	30.26 ± 2.54	0.28
Accuracy (%)^a
2back	84.60 ± 8.28 75~94	73.61 ± 7.62 64~96	54.78 ± 9.26 40~72	-
0back	97.31 ± 1.85 92~100	95.89 ± 5.52 78~100	77.36 ± 8.35 64~98
Reaction time (ms)^b
2back	625.60 ± 120.14 427.72~911.41	692.35 ± 119.49 549.6~944.74	729.35 ± 205.07 581.02~1056.8	-
0back	482.29 ± 50.22 383.46~585.06	529.27 ± 76.18 429.37~719.65	553.11 ± 114.04 466.47~857.02

SD standard deviation, WAIS-Digital the Digit Symbol Substitution Test of the Wechsler Adult Intelligence Scale, WAIS-Information the information subscale of the Wechsler Adult Intelligence Scale, CPZ chlorpromazine, SAPS Scale for Assessment of Positive Symptoms, SANS, Scale for the Assessment of Negative Symptoms
*p<0.05 significant difference was found
^aThe raw cognitive scores were calculated as the average of the Target and Non-target accuracies in N back tasks
^bReaction time was calculated as the average of the Target and Non-target reaction time in N back tasks

ISSN: 1471-244X