Table 3 Neuroimmune parameters in alcohol use disorder patients by trauma exposure and PTSD status
No traumatic history (n = 47) | Trauma without PTSD (n = 107) | PTSD (n = 32) | Statistical value (df) | P-value | |
|---|---|---|---|---|---|
Parameter | Median (IQR) | Median (IQR) | Median (IQR) | ||
CRP | 0.5 (0.5–4.0) | 1.0 (0.5–4.0) | 1.0 (0.5–2.0) | 0.41 (2) | 0.813 |
IL-1RA | 112 (73.6–142.7) | 113 (88.6–147.0) | 110 (88.6–134.1) | 0.74 (2) | 0.691 |
IL-6 | 8.6 (6.8–10.9) | 9.5 (7.4–11.3) | 9.1 (7.3–10.9) | 0.39 (2) | 0.825 |
IL-10 | 9.5 (6.5–14.2) | 9.7 (7.2–14.0) | 10.2 (6.5–14.5) | 0.38 (2) | 0.828 |
TNF-a | 32.6 (25.0–38.8) | 31.9 (25.0–44.1) | 33.8 (25.0–40.4) | 0.196 (2) | 0.906 |
IFN-g | 90.1 (71.2–118.4) | 109.7 (77.3–136.5) | 104.9 (70.7–134.2) | 2.938 (2) | 0.230 |
Kynurenine/tryptophan ratio | 41.8 (33.7–51.9) | 44.5 (35.2–53.6) | 42.3 (31.4–47.9) | 2.213 (2) | 0.331 |
BDNF | 22.6 (17.3–31.8) | 25.5 (18.8–31.4) | 24.3 (21.2–31.3) | 0.343 (2) | 0.842 |