Fig. 1

Layout of the clinical decision support tool (CDST). The CDST allows clinicians and patients to enter simple demographic and clinical variables (i.e. age, gender, severity – top box) and discuss the relevance of the different side effects (there is a score 0 to 100 to select the best tolerability profile according to personal preferences – left and right boxes). At the centre of the figure, results are presented as bar graphs reporting the percentage allocated to each side effect and the ranking of the treatments, with the corresponding probability to be the best, the second best, etc. In this working example, the patient is a female, aged between 51 and 65 years old, with moderate severity of symptoms, who is really concerned about weight gain and sedation (the higher the score, the more important the adverse event to avoid). Legend: EPS, extra-pyramidal symptoms; QTc, corrected QT interval