What is the impact of child abuse on gray matter abnormalities in individuals with major depressive disorder: a case control study

Table 2 Regions of significantly different GMD in MDD patients compared to healthy controls

Anatomical Region	Side	BA	MNI coordinate, mm			Number of voxel	Zscore
			x	y	z
Increased gray matter density in MDD
Postcentral gyrus	L	4	−39	−27	52	210	3.99
Postcentral gyrus	R	4	36	−24	54	518	5.05
Parieto-occipital cortex	L	31	−8	−70	26	140	3.45
Parieto-occipital cortex	R	23	4	−64	18	166	3.91
Putamen	L		−26	4	−4	1219	4.90
Putamen	R		26	8	−6	2174	5.05
Thalamus	R		4	−27	2	3687	4.80
Hippocampus	L		−16	−36	−4		4.44
Hippocampus	R		24	−33	−1		4.98
Cerebellum (Declive)	L		−20	−75	−20	175	3.46
Cerebellum (Tuber of vermis)	R		3	−76	−26	621	4.19
Decreased gray matter density in MDD
Orbitofrontal cortex	L		−14	46	−18	139	4.08
Orbitofrontal cortex	R	11	20	62	−20	224	3.93
Dorsomedial prefrontal cortex	R	8	15	32	54	149	3.72
Dorsal anterior cingulate cortex	R	24	6	−21	39	153	3.45
Middle occipital gyrus	L		−36	−87	22	292	4.16
Middle occipital gyrus	R	18	38	−88	−8	497	4.71
Cuneus	L	17	−8	−98	10	245	4.40

Note: L left hemisphere, R right hemisphere, BA Brodmann’s area; the threshold was set at AlphaSim corrected p < 0.05

ISSN: 1471-244X