Study group | Inclusion criteria | Exclusion criteria |
---|---|---|
1200-MDD patients | (1) age between 18 and 55Â years at the time of enrollment; (2) diagnosis of MDD based on the Chinese Version of MINI according to DSM-IV TR; (3) first-episode or relapsed; (4) having the ability of reading and writing to complete the questionnaire and psychological assessment; (5) providing written confirmation of informed consent. | (1) lifetime or current diagnosis of other psychotic disorder, alcohol/substances dependence or cognitive impairment; (2) severe somatic diseases, such as severe cardio-cerebral vascular diseases, respiratory diseases, liver diseases, kidney diseases, or malignant tumors; (3) not signed the informed consent; (4) been engaging in other studies. |
600-MDD patients subgroup | Besides those same as 1200-MDD patients’, more inclusion criteria are as the follows: (1) first-episode or relapsed more than1 time in the past 3 years and in acute episode period; (2) total score of HRSD17 ≥ 14 when being screened; (3) not taking anti-depressant regularly in the past 2 weeks or should change anti-depressant according to the psychiatrist’s advice. | Besides those same as 1200-MDD patients’, more exclusion criteria are as the follows: (1) resistant depression (not improved after taking 2 kinds of anti-depressant with adequate dosage and duration; (2) having history of epilepsy; (3) taking MECT therapy in the past 3 months; (4) pregnant or breast-feeding. |
1200-Healthy controls | (1) age between 18 and 55Â years at the time of enrollment; (2) providing written confirmation of informed consent prior to engaging the study. | (1) lifetime or current diagnosis of any mental diseases; (2) severe somatic diseases, such as severe cardio-cerebral vascular diseases, respiratory diseases, liver diseases, kidney diseases, or malignant tumors; (3) not signed the informed consent; (4) been engaging other studies. |